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| Status |
Public on Mar 25, 2020 |
| Title |
Expression data from rat vocal fold at different periods after vocal fold injury (miRNA) |
| Platform organism |
synthetic construct |
| Sample organism |
Rattus norvegicus |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
Vocal cord healing is a dynamic process, and many genes and proteins are involved, which play varying roles at different regeneration stages after injury. Previous studies have shown that inflammatory responses occur at the early stage of vocal cord injury, where the fibroblasts proliferate exuberantly with intensive secretion and deposition of ECM. These activities reach the peak at 3-7 days and their intensity begins to decline 15 days later. A study based on the dermal system has shown that ECM remodeling during the repair of injury can last for several months. However, few studies have been conducted as to the dynamic changes of gene and microRNA expressions during the healing process of vocal cord injury. Plotting these changes will facilitate the understanding about the physiological changes during healing and the identification of key time points and target genes and microRNAs in fibrosis formation.
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| Overall design |
20 animals were randomly divided into 4 experimental groups based on time of sacrifice: uninjured control, and 1, 4 and 8 weeks after injury. Following sacrifice, the larynx was harvested, and the bilateral vocal folds were dissected under magnification.
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| Contributor(s) |
Wang H, Xu W |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Mar 24, 2020 |
| Last update date |
Mar 28, 2020 |
| Contact name |
李 玉琳 |
| Organization name |
Beijing Institute of Heart Lung and Blood Vessel Diseases
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| Street address |
2 Anzhen Rd, Chaoyang District,
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| City |
Beijing |
| ZIP/Postal code |
100029 |
| Country |
China |
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| Platforms (1) |
| GPL21572 |
[miRNA-4] Affymetrix Multispecies miRNA-4 Array [ProbeSet ID version] |
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| Samples (20)
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| Relations |
| BioProject |
PRJNA614953 |
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