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| Status |
Public on Jul 01, 2009 |
| Title |
Human Adrenocortical Tumors: normal cortex vs inactive adenoma vs cortisol secreting adenoma vs adrenocortical cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Transcriptional profiling of human adrenocortical tumors. Gene expression profile of normal adrenal cortex, hormonally inactive adenoma, cortisol-secreting Cushing-adenoma and primary adrenocortical cancer tissues were compared. The goal of this study was to identify significant differences in the gene expression of these groups. Further aim was to reveal biologically relevant pathogenetic pathways altered at transcriptional and posttranscriptional level, as well.
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| Overall design |
mRNA expression profiles of normal adrenal cortex, inactive adenoma, cortisol secreting adenoma and primary adrenocortical cancer tissues were compared. Biological replicates: 4 samples per each experimental group were investigated. Whole genome expression analysis was performed in a two-colour microarray design by comparing individual samples to a uniform reference pool of all samples examined on Agilent Whole Human Genome 4x44 K microarray platform.
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| Contributor(s) |
Szabó PM, Tömböl Z, Molnár V, Wiener Z, Tölgyesi G, Patócs A, Falus A, Rácz K, Igaz P |
| Citation(s) |
19546168 |
| |
| Submission date |
Feb 20, 2009 |
| Last update date |
Jan 23, 2019 |
| Contact name |
Zsófia Tömböl |
| Organization name |
Semmelweis University
|
| Department |
2nd Department of Medicine
|
| Street address |
Szentkirályi u. 46.
|
| City |
Budapest |
| ZIP/Postal code |
H-1088 |
| Country |
Hungary |
| |
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| Platforms (1) |
| GPL6480 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version) |
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| Samples (16)
|
| GSM372687 |
Normal adrenal cortex replicate4 |
| GSM372688 |
Inactive adenoma tissue replicate 1 |
| GSM372689 |
Inactive adenoma tissue replicate 2 |
| GSM372690 |
Inactive adenoma tissue replicate 3 |
| GSM372691 |
Inactive adenoma tissue replicate 4 |
| GSM372692 |
Cortisol-secreting adenoma tissue replicate1 |
| GSM372693 |
Cortisol-secreting adenoma tissue replicate2 |
| GSM372694 |
Cortisol-secreting adenoma tissue replicate3 |
| GSM372695 |
Cortisol-secreting adenoma tissue replicate4 |
| GSM372696 |
Primary adrenocortical cancer replicate 1 |
| GSM372697 |
Primary adrenocortical cancer replicate 2 |
| GSM372698 |
Primary adrenocortical cancer replicate 3 |
| GSM372699 |
Primary adrenocortical cancer replicate 4 |
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| Relations |
| BioProject |
PRJNA111909 |
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