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| Status |
Public on Feb 15, 2023 |
| Title |
MacroH2A2 knockdown vs control RNA-seq in primary glioblastoma cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Self-renewal is a crucial property of glioblastoma cells and is enabled by the choreographed function of chromatin regulators and transcription factors. Identifying targetable epigenetic mechanisms of self-renewal could represent an important step toward developing new and effective treatments for this universally lethal cancer. Here we uncover a targetable epigenetic axis of self-renewal mediated by the histone variant macroH2A2.
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| |
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| Overall design |
RNA-seq of primary glioblastoma cells with macroH2A2 knockdown shRNA or control after 7 days of doxycycline induction
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| Contributor(s) |
Nikolic A, Bobyn A, Ellestad K, Lun X, Johnston M, Gafiuk CJ, Zemp FJ, Ninkovic N, Berger ND, Dirks PB, Derksen D, Senger DL, Chan JA, Mahoney DJ, Gallo M |
| Citation(s) |
37244935 |
| |
| Submission date |
Apr 24, 2020 |
| Last update date |
Aug 25, 2023 |
| Contact name |
Marco Gallo |
| Organization name |
University of Calgary
|
| Department |
Biochemistry and Molecular Biology
|
| Lab |
Gallo lab
|
| Street address |
2500 University Dr NW
|
| City |
Calgary |
| State/province |
AB |
| ZIP/Postal code |
T2N 1N4 |
| Country |
Canada |
| |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA627954 |
| SRA |
SRP258364 |
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