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Series GSE151542 Query DataSets for GSE151542
Status Public on Feb 18, 2021
Title Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia [RNA-seq]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Regulatory T (Treg) cells promote recovery from lung injury. Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia.
 
Overall design Flow cytometry sorted lung Treg cells (CD3e+CD4+CD25hiFR4+) from 2-month-old or 18-month-old C57BL/6 mice at baseline or following challenge with influenza A virus and harvested on day 60 post-infection. n = 5 biological replicates per group.
 
Contributor(s) Singer BD, Morales-Nebreda L
Citation(s) 33600379
NIH grant(s)
Grant ID Grant title Affiliation Name
K08 HL128867 Regulatory T cell Uhrf1 and DNA methylation in repair of acute lung injury NORTHWESTERN UNIVERSITY AT CHICAGO Benjamin David Singer
R01 HL149883 Mechanisms of regulatory T cell-mediated recovery from severe influenza A virus infection NORTHWESTERN UNIVERSITY AT CHICAGO Benjamin David Singer
P01 AG049665 Disordered Proteostasis as a Driver of Disease in the Aging Lung NORTHWESTERN UNIVERSITY AT CHICAGO G R Scott Budinger
U19 AI135964 Successful Clinical Response In Pneumonia Therapy (SCRIPT) Systems Biology Center NORTHWESTERN UNIVERSITY AT CHICAGO RICHARD G WUNDERINK
F32 HL151127 Determinants of age-related regulatory T cell function during influenza A virus-induced lung injury. NORTHWESTERN UNIVERSITY AT CHICAGO Luisa Morales-Nebreda
T32 HL076139 Training Program In Lung Sciences NORTHWESTERN UNIVERSITY AT CHICAGO KAREN M RIDGE
T32 HL076139 Training Program In Lung Sciences NORTHWESTERN UNIVERSITY AT CHICAGO Jacob I Sznajder
T32 GM008152 Medical Scientist Training Program NORTHWESTERN UNIVERSITY AT CHICAGO Hossein Ardehali
Submission date Jun 01, 2020
Last update date Feb 22, 2021
Contact name Benjamin D. Singer
E-mail(s) benjamin-singer@northwestern.edu
Organization name Northwestern University Feinberg School of Medicine
Street address 303 E. Superior St., Simpson Querrey 5th floor
City Chicago
State/province Illinois
ZIP/Postal code 60611
Country USA
 
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (20)
GSM4584983 AgedTreg_flu_1_RNAseq
GSM4584984 AgedTreg_flu_2_RNAseq
GSM4584985 AgedTreg_flu_3_RNAseq
This SubSeries is part of SuperSeries:
GSE151543 Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia
Relations
BioProject PRJNA636352
SRA SRP265471

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Supplementary file Size Download File type/resource
GSE151542_raw_counts_GEO.txt.gz 704.7 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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