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Status |
Public on Feb 18, 2021 |
Title |
Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia [RNA-seq] |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
Regulatory T (Treg) cells promote recovery from lung injury. Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia.
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Overall design |
Flow cytometry sorted lung Treg cells (CD3e+CD4+CD25hiFR4+) from 2-month-old or 18-month-old C57BL/6 mice at baseline or following challenge with influenza A virus and harvested on day 60 post-infection. n = 5 biological replicates per group.
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Contributor(s) |
Singer BD, Morales-Nebreda L |
Citation(s) |
33600379 |
NIH grant(s) |
Grant ID |
Grant title |
Affiliation |
Name |
K08 HL128867 |
Regulatory T cell Uhrf1 and DNA methylation in repair of acute lung injury |
NORTHWESTERN UNIVERSITY AT CHICAGO |
Benjamin David Singer |
R01 HL149883 |
Mechanisms of regulatory T cell-mediated recovery from severe influenza A virus infection |
NORTHWESTERN UNIVERSITY AT CHICAGO |
Benjamin David Singer |
P01 AG049665 |
Disordered Proteostasis as a Driver of Disease in the Aging Lung |
NORTHWESTERN UNIVERSITY AT CHICAGO |
G R Scott Budinger |
U19 AI135964 |
Successful Clinical Response In Pneumonia Therapy (SCRIPT) Systems Biology Center |
NORTHWESTERN UNIVERSITY AT CHICAGO |
RICHARD G WUNDERINK |
F32 HL151127 |
Determinants of age-related regulatory T cell function during influenza A virus-induced lung injury. |
NORTHWESTERN UNIVERSITY AT CHICAGO |
Luisa Morales-Nebreda |
T32 HL076139 |
Training Program In Lung Sciences |
NORTHWESTERN UNIVERSITY AT CHICAGO |
KAREN M RIDGE |
T32 HL076139 |
Training Program In Lung Sciences |
NORTHWESTERN UNIVERSITY AT CHICAGO |
Jacob I Sznajder |
T32 GM008152 |
Medical Scientist Training Program |
NORTHWESTERN UNIVERSITY AT CHICAGO |
Hossein Ardehali |
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Submission date |
Jun 01, 2020 |
Last update date |
Feb 22, 2021 |
Contact name |
Benjamin D. Singer |
E-mail(s) |
benjamin-singer@northwestern.edu
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Organization name |
Northwestern University Feinberg School of Medicine
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Street address |
303 E. Superior St., Simpson Querrey 5th floor
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City |
Chicago |
State/province |
Illinois |
ZIP/Postal code |
60611 |
Country |
USA |
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Platforms (1) |
GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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Samples (20)
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This SubSeries is part of SuperSeries: |
GSE151543 |
Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia |
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Relations |
BioProject |
PRJNA636352 |
SRA |
SRP265471 |