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| Status |
Public on Sep 25, 2020 |
| Title |
A novel TLX1 driven T-ALL zebrafish model: comparative genomic analysis with other leukemia models |
| Organism |
Danio rerio |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We generated a new rag2-TLX1 driven T-ALL model in zebrafish. RNA sequencing was preformed on the developed TLX1 T-ALLs (sequencing performed in the Speleman lab). In addition, RNA sequencing was performed on various additional zebrafish T-ALL models (shrek, hulk, otg, hMYC, sequenced in the Frazer lab) to look at the molecular differences between the various existing T-ALL models.
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| Overall design |
RNA sequencing data from TLX1, shrek, hulk, otg T-ALL samples, wild type thymocytes sequenced in the Speleman lab, wild type thymocytes sequenced in the Frazer lab. Shrek, otg, hulk, hMYC preleukemic thymocytes
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| Contributor(s) |
Loontiens S, Vanhauwaert S, Depestel L, Dewyn G, Van Loocke W, Moore FE, Garcia EG, Batchelor L, Borga C, Squiban B, Malone-Perez M, Volders P, Olexiouk V, Van Vlierberghe P, Langenau DM, Frazer KJ, Durinck K, Speleman F |
| Citation(s) |
32591643 |
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| Submission date |
Jun 04, 2020 |
| Last update date |
Jan 04, 2021 |
| Contact name |
Siebe Loontiens |
| E-mail(s) |
siebe.loontiens@ugent.be
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| Organization name |
Ghent University
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| Department |
Center for Medical Genetics
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| Street address |
Corneel Heymanslaan 10
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| City |
Gent |
| ZIP/Postal code |
9000 |
| Country |
Belgium |
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| Platforms (2) |
| GPL20828 |
Illumina NextSeq 500 (Danio rerio) |
| GPL23274 |
Illumina HiSeq 3000 (Danio rerio) |
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| Samples (70)
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| Relations |
| BioProject |
PRJNA637328 |
| SRA |
SRP265974 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE151816_rawCountMatrix_Frazier.txt.gz |
1.6 Mb |
(ftp)(http) |
TXT |
| GSE151816_rawCountMatrix_SLT.txt.gz |
959.9 Kb |
(ftp)(http) |
TXT |
| GSE151816_rawCountMatrix_WT_Frazier.txt.gz |
309.4 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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