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| Status |
Public on Feb 25, 2021 |
| Title |
In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions [Pofut1_microarray] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The role of nutrient signaling processes in the fate decision of CD8 is incompletely understood. By performing in vivo pooled CRISPR-Cas9 screening, we uncovered nutrient signaling processes underpinning the dynamics and heterogeneity of CD8 T cell fate decisions.
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| Overall design |
We used microarrays to compare the global transcription profiles of WT or Pofut1-null P14 cells with or without NICD co-expression at day 7.5 post-infection from spleen.
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| Contributor(s) |
Huang H, Shi H, Chi H |
| Citation(s) |
33636132 |
| |
| Submission date |
Oct 27, 2020 |
| Last update date |
Mar 01, 2021 |
| Contact name |
Hongbo Chi |
| E-mail(s) |
hongbo.chi@stjude.org
|
| Organization name |
St Jude Children's Research Hospital
|
| Department |
Immunology
|
| Street address |
262 Danny Thomas Place
|
| City |
Memphis |
| State/province |
TN |
| ZIP/Postal code |
38105 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (16)
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| This SubSeries is part of SuperSeries: |
| GSE160341 |
In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions |
|
| Relations |
| BioProject |
PRJNA672667 |
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