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| Status |
Public on Jan 01, 2010 |
| Title |
Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver, Part A |
| Organism |
Xenopus laevis |
| Experiment type |
Expression profiling by array
|
| Summary |
Thyroid hormone (TH) controls the remodeling of the pancreas and the liver. TH-induces dedifferentiation of the exocrine pancreas to a progenitor state (Proc. Nat. Acad Sci. 105, 8962-8967 (2008)) and it remodels the endocrine pancreas (Dev. Biol. 328, 384-391 (2009)). The redifferentiated frog pancreas resembles closely the pancreas of other typical vertebrates. Two pancreas arrays were carried out. The first one studied gene expression changes at different developmental stages of Xenopus laevis during metamorphosis. The second array studies gene expression changes at varying times after the addition of TH to premetamorphic tadpoles.
Keywords: cell cycle design,co-expression design,reference design,time series design
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| Overall design |
Thyroid hormone (TH) controls remodeling of the pancreas. The micro array was carried out to identify changes in gene expression between the tadpole and frog pancreas. This is part 1, done on the 44K Xenopus platform. This dataset was used only for one pancreas experiment with several data points (control, 12h, 24h, 48h and frog). Each was made in triplicate.
Samples in all 3 parts of the study received the same thyroid hormone levels.
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| Citation(s) |
19896938 |
| |
| Submission date |
May 12, 2009 |
| Last update date |
Mar 21, 2012 |
| Contact name |
Donald Brown |
| E-mail(s) |
brown@ciwemb.edu
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| Organization name |
Carnegie Institution
|
| Department |
Department of Embryology
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| Street address |
3520 San Martin Dr
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| City |
Baltimore |
| State/province |
MD |
| ZIP/Postal code |
21218 |
| Country |
USA |
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| Platforms (1) |
| GPL8463 |
Carnegie Xenopus Laevis 44K Microarray (60-mer Oligo) |
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| Samples (16)
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| GSM402482 |
Tadpole pancreas Control replication 1 |
| GSM402483 |
Tadpole pancreas 12h replication 1 |
| GSM402484 |
Tadpole pancreas 24h replication 1 |
| GSM402485 |
Tadpole pancreas 48h replication 1 |
| GSM402486 |
Tadpole pancreas Control replication 2 |
| GSM402487 |
Tadpole pancreas 12h replication 2 |
| GSM402488 |
Tadpole pancreas 24h replication 2 |
| GSM402489 |
Tadpole pancreas 48h replication 2 |
| GSM402490 |
Tadpole pancreas Control replication 3 |
| GSM402491 |
Tadpole pancreas 12h replication 3 |
| GSM402492 |
Tadpole pancreas 24h replication 3 |
| GSM402493 |
Tadpole pancreas 48h replication 3 |
| GSM402494 |
Tadpole pancreas Control replication 4 |
| GSM402495 |
Adult pancreas Frog replication 1 |
| GSM402496 |
Adult pancreas Frog replication 2 |
| GSM402497 |
Adult pancreas Frog replication 3 |
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| This SubSeries is part of SuperSeries: |
| GSE16075 |
Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver |
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| Relations |
| BioProject |
PRJNA123097 |
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