|
| Status |
Public on May 19, 2009 |
| Title |
Expression data of HL-60 leukemia cells after treatment with Curcumin and TCDD |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Curcumin has antileukemic potential that is mediated by dfifferent pathways. Because we could not confirm that the Arylhydrocarbonreceptor, a ligand activated transcription factor, is involved in curcumins antileukemic effects, we performed microarray experiments to have an overall screening of the pathways affected by curcumin in HL-60 cells.
We identified an involvement of the vitamin D receptor in the effects of curcumin on HL-60 cells by comparing our results with other experiments.
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| |
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| Overall design |
HL-60 cells were treated for 24h with 100 µM curcumin, 10 nM 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), or 0.5 % DMSO as control.
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| |
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| Contributor(s) |
Esser C, Goergens A, Frericks M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
May 19, 2009 |
| Last update date |
Dec 06, 2018 |
| Contact name |
Charlotte Esser |
| E-mail(s) |
schloepi@gmx.de
|
| Phone |
00492113389252
|
| URL |
http://www.iuf.uni-duesseldorf.de/
|
| Organization name |
IUF
|
| Department |
Immunologie
|
| Street address |
Aufm Hennekamp 50
|
| City |
Düsseldorf |
| State/province |
NRW |
| ZIP/Postal code |
40225 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
|
| Samples (6)
|
| GSM405497 |
HL-60 + 100 µM curcumin, biological replicate 1 |
| GSM405498 |
HL-60 + 100 µM curcumin, biological replicate 2 |
| GSM405499 |
HL-60 + 10 nM TCDD, biological replicate 1 |
| GSM405500 |
HL-60 + 10 nM TCDD, biological replicate 2 |
| GSM405501 |
HL-60 + 0.5 % DMSO, biological replicate 1 |
| GSM405502 |
HL-60 + 0.5 % DMSO, biological replicate 2 |
|
| Relations |
| BioProject |
PRJNA117183 |
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