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| Status |
Public on Dec 07, 2023 |
| Title |
lncRNA and mRNA expression data of periosteum from patients with Legg-Calve-Perthes disease (LCPD) and Control patients (with femoral fracture/coxa valga) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Since the first recognition of LCPD as a separate disease entity in 1910, numerous theories about the etiology of the disease have been proposed. However, none have been validated conclusively, and the underlying mechanisms and determinants of LCPD still remain unclear
Many lncRNAs have been regarded as diagnostic biomarkers or therapeutic targets.However, the lncRNA expression profiles and the potential regulatory network in the development of LCPD have not been investigated. In this study, we aimed at profiling differentially expressed lncRNA and mRNA and constructing lncRNA-mRNA interacting networks in LCPD tissues to identify novel potential targets for a better understanding of the pathogenesis of LCPD
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| Overall design |
Periosteum specimens (size: about 1 cm × 0.5 cm) were biopsied from the proximal femur of each patient during surgery and transferred to liquid nitrogen immediately after being washed with saline. Informed consent was obtained from the patient's guardians, and this study was approved by the Ethics Committee of Tongji Medical College. The lncRNA and mRNA expression profiling analysis was performed by Genminix Informatics Ltd., Co. (Shanghai, China) using GeneChip™ Human Transcriptome Assay (HTA) 2.0 (Affymetrix, USA)
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| Contributor(s) |
Tang X |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Dec 07, 2020 |
| Last update date |
Dec 07, 2023 |
| Contact name |
Xin Tang |
| Organization name |
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
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| Street address |
1277 jiefang avenue
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| City |
Wuhan |
| ZIP/Postal code |
430022 |
| Country |
China |
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| Platforms (1) |
| GPL17586 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
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| Samples (15)
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| GSM4959531 |
proximal femur periosteum, LCPD4 |
| GSM4959532 |
proximal femur periosteum, LCPD5 |
| GSM4959533 |
proximal femur periosteum, LCPD6 |
| GSM4959534 |
proximal femur periosteum, LCPD7 |
| GSM4959535 |
proximal femur periosteum, LCPD8 |
| GSM4959536 |
proximal femur periosteum, LCPD9 |
| GSM4959537 |
proximal femur periosteum, Ctrl1 |
| GSM4959538 |
proximal femur periosteum, Ctrl2 |
| GSM4959539 |
proximal femur periosteum, Ctrl3 |
| GSM4959540 |
proximal femur periosteum, Ctrl4 |
| GSM4959541 |
proximal femur periosteum, Ctrl5 |
| GSM4959542 |
proximal femur periosteum, Ctrl6 |
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| Relations |
| BioProject |
PRJNA682996 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE162766_RAW.tar |
342.2 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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