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Series GSE164612 Query DataSets for GSE164612
Status Public on Apr 13, 2021
Title Expression data from stabilized epithelial pancreatic cancer cells
Organism Mus musculus
Experiment type Expression profiling by array
Summary Pancreatic ductal adenocarcinoma is therapeutically recalcitrant and metastatic. Epithelial to mesenchymal transition (EMT) is associated with metastasis, however, a causal connection needs further unraveling. We explored the impact of stabilized EMT states on PDAC metastasis through the use of genetically-engineered mouse models that exhibit a stabilized epithelial phenotype through the deletion of EMT-driving transcription factors Snail and Twist together
We examined the cancer cell-intrinsic pathways associated with stabilized epithelial pancreatic adenocarcinoma cells.
 
Overall design YFP+ cancer cells were freshly sorted from the primary pancreatic tumors and the most common metastatic sites, liver and lung, of the KPC and KPC;Snai1cKO; Twist1cKO mice for global expression profiling using the Clariom D mouse whole transcriptome array.
 
Contributor(s) Kalluri R, Carstens JL
Citation(s) 33852841
Submission date Jan 11, 2021
Last update date May 06, 2021
Contact name Raghu Kalluri
E-mail(s) rkalluri@mdanderson.org
Organization name MD Anderson Cancer Center
Department Cancer Biology
Street address 1881 East Road
City Houston
State/province TX
ZIP/Postal code 77054
Country USA
 
Platforms (1)
GPL20775 [MTA-1_0] Affymetrix Mouse Transcriptome Array 1.0 [transcript (gene) CSV version]
Samples (19)
GSM5014812 KPC Control YFP+ cancer cells from primary tumor - mouse 978U
GSM5014813 KPC Control YFP+ cancer cells from Lung - mouse 978U
GSM5014814 KPC Control YFP+ cancer cells from primary tumor - mouse H410
Relations
BioProject PRJNA691336

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE164612_RAW.tar 446.9 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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