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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Mar 13, 2021 |
| Title |
ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Cyclic dinucleotide (CDN) agonists of the STimulator of InterferoN Genes (STING) pathway have shown immune activation and tumor clearance in pre-clinical models. However, CDNs administered intratumorally also promote STING activation leading to direct cytotoxicity of many cell types in the tumor microenvironment (TME), systemic inflammation due to rapid tumor extravasation of the CDN, and immune ablation in the TME. These result in a failure to establish immunological memory. ExoSTING, an engineered extracellular vesicle (EV) exogenously loaded with CDN, enhances the potency of CDN and preferentially activates antigen presenting cells in the TME. Following intratumoral injection, exoSTING was retained within the tumor, enhanced local Th1 responses and recruitment of CD8+ T cells, and generated systemic anti-tumor immunity to the tumor. ExoSTING at therapeutically active doses did not induce systemic inflammatory cytokines, resulting in an enhanced therapeutic window. ExoSTING is a novel, differentiated therapeutic candidate that leverages the natural biology of EVs to enhance the activity of CDNs.
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| Overall design |
Examination of mRNA profile in B16F10 tumors after exoSTING treatment
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| Contributor(s) |
Jang SC, Zhang K |
| Citation(s) |
33888863 |
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| Submission date |
Mar 12, 2021 |
| Last update date |
Jun 12, 2021 |
| Contact name |
Kelvin Zhang |
| Organization name |
Codiak Biosciences
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| Street address |
35 CambridgePark Drive, Suite 500
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| City |
Cambridge |
| State/province |
Massachusetts |
| ZIP/Postal code |
02140 |
| Country |
USA |
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| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA713983 |
| SRA |
SRP310384 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE168784_exoSTING_raw_counts.txt.gz |
1.1 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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