|
| Status |
Public on Nov 17, 2021 |
| Title |
Endothelial cell-specific reduction of heparan sulfate suppresses glioma growth in mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
we examined how HS-reduced vascular endothelial cells are involved in the proliferation of glioma by using mice in which Ext-1 expression is specifically suppressed in vascular endothelial cells.
|
| |
|
| Overall design |
We prepared mouse glioma (GL261) cells. We transplanted the cells to wild type (WT) and Ext1 flox/flox; VE-Cre mice (N=4 each). We removed the developing tumors from mouse brain 14 to 21 days later and extracted RNA from whole tumors. Finally, we perfomred RNA microarray analysis.
|
| |
|
| Contributor(s) |
Tomita H, Kinoshita T |
| Citation(s) |
34790962 |
|
https://doi.org/10.1007/s12672-021-00444-3
|
| |
| Submission date |
May 24, 2021 |
| Last update date |
Nov 30, 2021 |
| Contact name |
Hiroyuki Tomita |
| Organization name |
Gifu University
|
| Street address |
1-1 Yanagido
|
| City |
Gifu |
| ZIP/Postal code |
5011194 |
| Country |
Japan |
| |
|
| Platforms (1) |
| GPL21163 |
Agilent-074809 SurePrint G3 Mouse GE v2 8x60K Microarray [Probe Name version] |
|
| Samples (8)
|
|
| Relations |
| BioProject |
PRJNA732371 |
Less...
More...