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| Status |
Public on Jun 30, 2021 |
| Title |
Probing tumorigenic potentials of the genetic interactions reconstituted in murine fallopian tube organoids |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Despite histological diversity in the subcutaneous nodules and tumors, the derived tumor-derived organoids stereotypically exhibited cystic featuresTo clarify molecular differences among the p53-null falopian tube-derived tumors driven by KrasG12D, Pik3caH1047R, and Apc580D, the transcriptome across tumor-derived organoidss, originating organoids before inoculation, p53-null organoids without driver mutations, and organoids without recombination as a reference were compared.
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| Overall design |
The Trp53flox/flox mice-derived FT organoids transduced with the control vector pLKO.1 served as a reference for gene expression. Three pairs of organoids before injection and derived from tumors were analyzed.
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| Contributor(s) |
Hippo Y, Maru Y |
| Citation(s) |
34184756 |
| Submission date |
May 25, 2021 |
| Last update date |
Oct 07, 2021 |
| Contact name |
Yoshitaka Hippo |
| E-mail(s) |
yhippo@chiba-cc.jp
|
| Organization name |
Chiba Cancer Center
|
| Street address |
666-2 Nitona-cho, Chuo-ku
|
| City |
Chiba |
| State/province |
Chiba |
| ZIP/Postal code |
260-8717 |
| Country |
Japan |
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| Platforms (1) |
| GPL21163 |
Agilent-074809 SurePrint G3 Mouse GE v2 8x60K Microarray [Probe Name version] |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA732676 |
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