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| Status |
Public on Jun 09, 2021 |
| Title |
Genomic alterations in Reinke's edema |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by genome tiling array
|
| Summary |
Reinke's edema (RE) is a laryngeal lesion related to excessive tobacco smoking, voice overuse, and laryngopharyngeal reflux. Although the risk of malignancy is low, RE has been classified among premalignant lesions. Array-based comparative genomic hybridization (aCGH) was used to investigate DNA copy number alterations (CNA) and as a tool to identify markers of risk stratification.
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| Overall design |
Genomic profiling of eight surgical specimens of RE was evaluated by aCGH (Agilent 4x180K platform). CNAs were compared with the Database of Genomic Variants (DGV) and genes mapped on altered regions with annotated functions.
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| Contributor(s) |
Móz LE, Villacis RA |
| Citation(s) |
36243603 |
| |
| Submission date |
Jun 09, 2021 |
| Last update date |
May 02, 2023 |
| Contact name |
Rolando Andre Rios Villacis |
| E-mail(s) |
rolando.andre@unb.br
|
| Phone |
+5561996912223
|
| Organization name |
University of Brasília - UnB
|
| Department |
Genetics and Morphology
|
| Lab |
Genetic Toxicology
|
| Street address |
Asa Norte
|
| City |
Brasília |
| State/province |
DF |
| ZIP/Postal code |
70910-900 |
| Country |
Brazil |
| |
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| Platforms (1) |
| GPL10150 |
Agilent-022060 SurePrint G3 Human CGH Microarray 4x180K (Probe Name version) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA736237 |
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