NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE180770 Query DataSets for GSE180770
Status Public on Jul 26, 2021
Title CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response
Organism Danio rerio
Experiment type Expression profiling by high throughput sequencing
Summary CD44 is a transmembrane adhesion molecule and the major receptor for hyaluronan. The function of CD44 has been implicated in numerous biological processes. Our study finds that zebrafish CD44a variants function as positive regulators in antibacterial response. In order to reveal the possible antibacterial mechanism of CD44a, the wild-type and CD44a-/--14del zebrafish larvaes infected with E. piscicida collected at 24 and 48 hpi were used for transcriptome sequencing. Our data demonstrate that zebrafish CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response.
 
Overall design The hatched larvae (4 dpf) from wild-type and CD44a mutants (CD44a-/--14del) were infected with E. piscicida, the infection was performed in triplicate with a parallel group with 50 fish per group. At 24hpi and 48hpi; the larvae in each group was collected for cDNA Library Construction and Illumina Deep Sequencing.
 
Contributor(s) Cao L, Chang MX
Citation(s) 36042265
Submission date Jul 24, 2021
Last update date Sep 15, 2022
Contact name cao lu
E-mail(s) caolu@ihb.ac.cn
Phone +8618202736768
Organization name Institute of Hydrobiology
Department Chinese Academy of Sciences
Street address 7 Donghu South Road
City Wuhan
State/province Hubei
ZIP/Postal code 430072
Country China
 
Platforms (1)
GPL24995 Illumina NovaSeq 6000 (Danio rerio)
Samples (12)
GSM5470591 E24WT1
GSM5470592 E24WT2
GSM5470593 E24WT3
Relations
BioProject PRJNA749459
SRA SRP329694

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE180770_E2422C1_22C2_22C3.txt.gz 33.8 Kb (ftp)(http) TXT
GSE180770_E24WT1_WT2_WT3.txt.gz 33.9 Kb (ftp)(http) TXT
GSE180770_E4822C1_22C2_22C3.txt.gz 23.0 Kb (ftp)(http) TXT
GSE180770_E48WT1_WT2_WT3.txt.gz 23.0 Kb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap
External link. Please review our privacy policy.