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Series GSE18608 Query DataSets for GSE18608
Status Public on Dec 17, 2010
Title Transcriptional Profiling of CD133+ Cells in Coronary Artery Disease and Effects of Exercise on Gene Expression
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Bone marrow-derived progenitor cells are under investigation for cardiovascular repair, but may be altered by disease. We identified 82 differentially expressed genes in CD133+ cells from patients with coronary artery disease (CAD) versus controls, of which 59 were found to be up-regulated and 23 down-regulated. These genes were found to be involved in carbohydrate metabolism, cellular development and signaling, molecular transport and cell differentiation. Following completion of an exercise program, gene expression patterns resembled those of controls in 7 of 10 patients.
 
Overall design Blood sampled from 4 healthy subjects (H), and from 10 patients with coronary artery disease at baseline (A) and after 3 months (B) of exercise.
 
Contributor(s) Cannon R Jr
Citation(s) 21235297
Submission date Oct 16, 2009
Last update date Mar 25, 2019
Contact name Delong Liu
E-mail(s) liud2@mail.nih.gov
Phone 301-451-7129
Organization name NHLBI/NIH
Street address 10 Center Drive
City Bethesda
State/province MD
ZIP/Postal code 20892
Country USA
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (24)
GSM462608 transcriptional profiling of CD133+ cells in coronary artery disease, SG-6A
GSM462609 transcriptional profiling of CD133+ cells in coronary artery disease, SG-6B
GSM462610 transcriptional profiling of CD133+ cells in coronary artery disease, SG-7A
Relations
BioProject PRJNA121435

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE18608_RAW.tar 97.1 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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