|
| Status |
Public on Dec 21, 2021 |
| Title |
Identification and tracking of alloreactive T cell clones in Rhesus Macaques (RM) through the RM-scTCR-Seq platform |
| Organism |
Macaca mulatta |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
T cell receptor clonotype tracking is a powerful tool for interrogating T cell mediated immune processes We apply this method to a Rhesus Macaque model of Graft Versus Host Disease (GvHD), and identify and track in vitro detected alloreactive clonotypes in GvHD target organs and explore their GvHD driven cytotoxic T cell signature.
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| |
|
| Overall design |
Examination of scTCR-Seq and scRNA-Seq of T cells in RM model of GvHD and in vitro MLR experiments.
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| |
|
| Contributor(s) |
Gerdemann U, Fleming RA, Kaminski J |
| Citation(s) |
35154078 |
| Submission date |
Dec 06, 2021 |
| Last update date |
Mar 23, 2022 |
| Contact name |
Jim Kaminski |
| E-mail(s) |
James.Kaminski@childrens.harvard.edu
|
| Organization name |
Boston Children's Hospital
|
| Street address |
1 Blackfan Circle
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02115 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL27943 |
Illumina NovaSeq 6000 (Macaca mulatta) |
|
| Samples (44)
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|
| Relations |
| BioProject |
PRJNA786559 |
| SRA |
SRP349418 |
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