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| Status |
Public on Dec 31, 2022 |
| Title |
An organoid-based transplantation model reveals genetic interactions potentiating niche-independent gastric carcinogenesis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Despite distinct genetic aberrations introduced and diverse tumor histology, the derived tumor-derived organoids stereotypically exhibited cystic features. To clarify distinct genotype-dependent properties of p53-null tumor-derived organoids, seven tumor-derived organoids and organoids with pLKO.1 and shLuc were compared.
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| Overall design |
The Trp53flox/flox mice-derived Ga organoids transduced with the control vector pLKO.1 and shLuc served as a reference for gene expression. seven tumor-derived organoids were analyzed.
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| Contributor(s) |
Hippo Y, Maru Y |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Dec 26, 2021 |
| Last update date |
Jan 02, 2023 |
| Contact name |
Yoshitaka Hippo |
| E-mail(s) |
yhippo@chiba-cc.jp
|
| Phone |
0432645431
|
| Organization name |
Chiba Cancer Center Research Institute
|
| Street address |
Nitona-cho 666-2
|
| City |
Chiba |
| State/province |
chiba |
| ZIP/Postal code |
260-8717 |
| Country |
Japan |
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| Platforms (1) |
| GPL21163 |
Agilent-074809 SurePrint G3 Mouse GE v2 8x60K Microarray [Probe Name version] |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA792333 |
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