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Series GSE192797 Query DataSets for GSE192797
Status Public on Dec 06, 2023
Title Thyroid hormone receptor agonist promotes hair growth in mice
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We report the application of RNA-sequencing technology for topical application of the thyroid hormone receptor agonist (TDM10842) in murine skin tissue. Twenty-nine 8-week-old C3H mice were obtained, and randomly divided into 3 groups, after depilation, with topical use of TDM, Vehicle and Blank respectively. We found 857, 782, and 276 differentially expressed genes were identified from the skin tissue between 3 groups. Weighted correlation network analysis (WGCNA) was used to find clusters of highly correlated genes from the 3 groups. From which, we found one gene, Pclaf, as a differentially expressed gene compared with the other two groups. We scored their pathway activities. We found that signaling pathway of E2F TARGETS, G2M CHECKPOINT, MYC TARGET V1, HEDGEHOG SIGNALING, MYC TARGET V2, WNT BETA CATENIN SIGNALING, EPITHELIAL MESENCHYMAL TRANSITION, MITOTIC SPINDLE, UNFOLDED PROTEIN RESPONSE and DNA REPAIR were up regulated in the TDM group compared with the other 2 control groups.
 
Overall design RNA-seq in mice skin tissue after topical application of the thyroid hormone receptor agonist.
 
Contributor(s) Zhu P, Deng W, Yu J, Yang S
Citation https://doi.org/10.2147/CCID.S354219
Submission date Dec 30, 2021
Last update date Dec 06, 2023
Contact name Peiqiu Zhu
E-mail(s) 1911110289@bjmu.edu.cn
Phone 86-18801229335
Organization name Peking University First Hospital
Department Dermatology
Street address Xishiku Street 8
City Beijing
ZIP/Postal code 100034
Country China
 
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (27)
GSM5765467 Mice skin tissue-Blank1
GSM5765468 Mice skin tissue-Blank2
GSM5765469 Mice skin tissue-Blank3
Relations
BioProject PRJNA793234

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Supplementary file Size Download File type/resource
GSE192797_all_counts-fkpm.xlsx 26.8 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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