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Series GSE198925 Query DataSets for GSE198925
Status Public on Jul 01, 2022
Title MLID imprinting disorders
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary Genomic imprinting is the parent-of-origin-specific allelic transcriptional silencing observed in mammals, which is governed by DNA methylation established in the gametes and maintained throughout the development. The frequency and extent of epimutations associated with the nine reported imprinting syndromes varies because it is evident that aberrant preimplantation maintenance of imprinted differentially methylated regions (DMRs) may affect multiple loci. Using a custom Illumina GoldenGate array targeting 27 imprinted DMRs, we profiled allelic methylation in 8 imprinting defect patients.
 
Overall design DNA samples extracted from peripheral blood were subjected to methylation profile analysis using a custom Illumina Veracode GoldenGate Methylation array. We include 15 patients and 28 individuals as control samples, ages between 1-35 years.
 
Contributor(s) Court F, Martin-Trujillo A, Romanelli V, Garin I, Iglesias-Platas I, Pereda A, Perez de Nanclares G, Monk D
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Mar 18, 2022
Last update date Jul 03, 2022
Contact name Guiomar Perez de Nanclares
E-mail(s) gnanclares@osakidetza.eus
Phone 0034945007097
Organization name Bioaraba Health Research Institute
Department (Epi)Genetics Lab
Lab (Epi)Genetics Lab
Street address Jose Atxotegi sn
City Vitoria-Gasteiz
State/province Araba
ZIP/Postal code 01009
Country Spain
 
Platforms (1)
GPL18246 Illumina Custom VeraCode GoldenGate Methylation Assay (GGMA) microarray
Samples (43)
GSM5960767 DM1170
GSM5960768 DM0741
GSM5960769 DM0724
Relations
BioProject PRJNA817519

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE198925_RAW.tar 1.3 Mb (http)(custom) TAR (of IDAT)
GSE198925_average_betas.txt.gz 79.7 Kb (ftp)(http) TXT
GSE198925_signal_intensities_annotations.txt.gz 183.4 Kb (ftp)(http) TXT
Processed data are available on Series record

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