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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jan 20, 2010 |
| Title |
In vivo actin cross-linking induced by type VI secretion system is associated with intestinal inflammation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
To determine whether the Vibrio cholerae type VI secretion system (T6SS) is functional during animal infection, derivatives of V52 were used to infect infant mice. In this infection model, a diarrheal response occurred and effector translocation could be detected. These host responses were dependent on a functional T6SS and on the actin cross-linking effector domain of VgrG-1.
Gene expression and histological studies showed innate immune activation and immune cell infiltration in the intestinal lumen.
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| Overall design |
3 infection groups (mock, V52, ACD), 3 biological replicates per group.
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| Contributor(s) |
Ma A, Mekalanos J |
| Citation(s) |
20150509 |
| Submission date |
Jan 19, 2010 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Amy Ma |
| Organization name |
Harvard Medical School
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| Department |
Microbiology
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| Street address |
200 Longwood Ave D1-411
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| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02115 |
| Country |
USA |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (9)
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| GSM498429 |
intestine, mock-infected, biol rep1 |
| GSM498430 |
intestine, V52-infected, biol rep1 |
| GSM498431 |
intestine, ACD-infected, biol rep1 |
| GSM498432 |
intestine, mock-infected, biol rep2 |
| GSM498433 |
intestine, V52-infected, biol rep2 |
| GSM498434 |
intestine, ACD-infected, biol rep2 |
| GSM498435 |
intestine, mock-infected, biol rep3 |
| GSM498436 |
intestine, V52-infected, biol rep3 |
| GSM498437 |
intestine, ACD-infected, biol rep3 |
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| Relations |
| BioProject |
PRJNA120179 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE19946_RAW.tar |
36.7 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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