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| Status |
Public on Jun 13, 2022 |
| Title |
Fibroblast-specific reduction of heparan sulfate suppresses colon tumor growth in mice |
| Platform organism |
Mus musculus |
| Sample organism |
Mus |
| Experiment type |
Expression profiling by array
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| Summary |
we examined how HS-reduced fibroblasts are involved in the proliferation of colon cancer by using mice in which Ext-1 expression is specifically suppressed in fibroblasts.
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| Overall design |
We prepared mouse colon cancer (MC38) cells. We transplanted the cells to wild type (WT) and Ext1 flox/flox; S100a4-Cre mice (N=4 each). We removed the developing tumors from mouse subcutaneous area 25 to 30 days later and extracted RNA from whole tumors. Finally, we performed RNA microarray analysis.
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| Contributor(s) |
Tomita H, Niwa A |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
May 23, 2022 |
| Last update date |
Jun 15, 2022 |
| Contact name |
Ayumi Niwa |
| Organization name |
Gifu University
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| Street address |
1-1 Yanagido
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| City |
Gifu City |
| ZIP/Postal code |
501 - 1194 |
| Country |
Japan |
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| Platforms (1) |
| GPL21163 |
Agilent-074809 SurePrint G3 Mouse GE v2 8x60K Microarray [Probe Name version] |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE203602 |
Fibroblast-specific reduction of heparan sulfate suppresses colon tumor growth and pancreatic cancer growth in mice |
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| Relations |
| BioProject |
PRJNA841566 |
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