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Series GSE205151 Query DataSets for GSE205151
Status Public on Jun 05, 2022
Title Functional Immunophenotyping of Children with Critical Status Asthmaticus Identifies Differential Gene Expression Responses in Neutrophils Exposed to a Poly(I:C) Stimulus
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We determined whether we could identify clusters of children with critical asthma by functional immunophenotyping using an intracellular viral analog stimulus.
We performed a single-center, prospective, observational cohort study of 43 children ages 6 – 17 years admitted to a pediatric intensive care unit for an asthma attack between July 2019 to February 2021.
 
Overall design Neutrophils were isolated from children, stimulated overnight with LyoVec poly(I:C), and mRNA was analyzed using a targeted Nanostring immunology array. Network analysis of the differentially expressed transcripts for the paired LyoVec poly(I:C) samples was performed.
 
Contributor(s) Grunwell JR, Kamaleswaran R
Citation(s) 36385161
Submission date May 31, 2022
Last update date Nov 29, 2022
Contact name Milad Rad
Organization name Georgia Institute of Technology
Department School of Electrical and Computer Engineering
Street address 266 Ferst Dr NW
City Atlanta
State/province GA
ZIP/Postal code 30332
Country USA
 
Platforms (1)
GPL21847 nCounter Nanostring Human Immunology v2 (Catalog #115000061)
Samples (144)
GSM6205808 Patient 1 untreated
GSM6205809 Patient 1 polyIC
GSM6205810 Patient 2 untreated
Relations
BioProject PRJNA844008

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE205151_RAW.tar 1.0 Mb (http)(custom) TAR (of RCC)
Processed data included within Sample table

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