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Series GSE213053 Query DataSets for GSE213053
Status Public on Dec 07, 2022
Title Domestic dog lineages reveal genetic drivers of behavioral diversification
Platform organism Canis lupus familiaris
Sample organisms Canis lupus; Canis lupus familiaris; Canis lupus dingo
Experiment type SNP genotyping by SNP array
Genome variation profiling by SNP array
Summary Selective breeding of domestic dogs has generated diverse breeds often optimized for performing specialized tasks. Despite the heritability of breed-typical behavioral traits, identification of causal loci has proven challenging due to the complexity of canine population structure. We overcome longstanding difficulties in identifying genetic drivers of canine behavior by developing an innovative framework for understanding relationships between breeds and the behaviors that define them utilizing genetic data for over 4,000 domestic, semi-feral and wild canids and behavioral survey data for over 46,000 dogs. We identify ten major canine genetic lineages and their behavioral correlates and show that breed diversification is predominantly driven by non-coding regulatory variation. We determine that lineage-associated genes converge in neurodevelopmental co-expression networks, identifying a sheepdog-associated enrichment for interrelated axon guidance functions. This work presents a scaffold for canine diversification that positions the domestic dog as an unparalleled system for revealing the genetic origins of behavioral diversity.
Overall design 946 dogs, 9 dingoes, and 1 wolf
Contributor(s) Dutrow EV, Serpell JA, Ostrander EA
Citation(s) 36493753
Submission date Sep 09, 2022
Last update date Mar 08, 2023
Contact name Alexander Christian Harris
Phone 301-402-2016
Organization name National Institutes of Health
Department National Human Genome Research Institute
Lab Ostrander
Street address 50 South Drive
City Bethesda
State/province Maryland
ZIP/Postal code 20892
Country USA
Platforms (1)
GPL17481 Illumina CanineHD BeadChip
Samples (956)
GSM6569829 PHAR [30606]
GSM6569830 PHAR [31082]
GSM6569831 PHAR [31095]
BioProject PRJNA879418

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE213053_GEO_Dutrow_2022Sep07_DetailedGenotypes.txt.gz 1.0 Gb (ftp)(http) TXT
GSE213053_GEO_Dutrow_2022Sep07_MatrixIntensities.txt.gz 2.0 Gb (ftp)(http) TXT
GSE213053_GEO_Dutrow_2022Sep07_MatrixProcessed.txt.gz 2.5 Gb (ftp)(http) TXT
GSE213053_RAW.tar 2.5 Gb (http)(custom) TAR (of IDAT)
Processed data are available on Series record

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