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| Status |
Public on Nov 10, 2022 |
| Title |
HDAC9-mediated Epithelial Cell Cycle Arrest in G2/M Contributes to Kidney Fibrosis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Renal tubulointerstitial fibrosis is the pathological feature of AAN. Aristolochic acid nephropathy (AAN)was induced by a one-time intraperitoneal injection of aristolochic acid in PBS. By RNA sequencing analysis in AAN mice, we observed the significant changes of genes important in regulating cell cycle.
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| Overall design |
We established the mouse model of AAN to explore the precise mechanism.
The gene expression of 6 samples from the AAN mice was compared to 4 sham samples by RNA sequencing.
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| Contributor(s) |
Zhang Y, Liu M |
| Citation(s) |
37230975 |
| |
| Submission date |
Nov 03, 2022 |
| Last update date |
Aug 25, 2023 |
| Contact name |
Zhang Yang |
| E-mail(s) |
201915118@mail.sdu.edu.cn
|
| Phone |
17863129058
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| Organization name |
Shandong University
|
| Department |
Department of Pharmacology
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| Street address |
44 Wenhua West Road
|
| City |
Jinan |
| ZIP/Postal code |
250012 |
| Country |
China |
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| Platforms (1) |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA897857 |
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