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| Status |
Public on Nov 08, 2023 |
| Title |
Features and protective efficacy of human monoclonal antibodies targeting M. tuberculosis arabinomannan |
| Platform organism |
synthetic construct |
| Sample organism |
Homo sapiens |
| Experiment type |
Protein profiling by protein array
|
| Summary |
Human antibody responses to AM/LAM are heterogenous and knowledge of reactivity to specific glycan epitopes at the monoclonal level is limited.
Using novel glycan arrays, we characterized a very high affinity monoclonal antibody P1AM25 to AM/LAM, determined this mAb recognized distinct glycan epitopes from other anti-AM/LAM mAbs reported.
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| Overall design |
Monoclonal antibodies at 5 ug/ml were tested for direct binding to 61 synthetic oligosaccharides
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| Contributor(s) |
Liu Y, Chen T, Lowary TL, Achkar JM |
| Citation(s) |
37733444 |
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| Submission date |
Nov 28, 2022 |
| Last update date |
Nov 09, 2023 |
| Contact name |
Jacqueline M. Achkar |
| Organization name |
Albert Einstein College of Medicine
|
| Street address |
1300 Morris Park Avenue
|
| City |
Bronx |
| ZIP/Postal code |
10461 |
| Country |
USA |
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| Platforms (1) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA906063 |
