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Series GSE219090 Query DataSets for GSE219090
Status Public on Dec 14, 2022
Title The dogs of Chernobyl: demographic insights into populations inhabiting the nuclear exclusion zone
Organism Canis lupus familiaris
Experiment type Genome variation profiling by SNP array
Summary The 1986 Chernobyl nuclear disaster initiated a series of catastrophic events resulting in long-term and widespread environmental contamination. We characterize the genetic structure of 302 dogs representing three free-roaming dog populations living within the power plant itself, or 15-45 km from the disaster site. Genome-wide profiles from Chernobyl, purebred, and free-breeding dogs world-wide reveal that the individuals from the power plant and Chernobyl City are genetically distinct, with the former displaying increased intrapopulation genetic similarity and differentiation. Analysis of shared ancestral genome segments highlights differences in the extent and timing of western breed introgression. Kinship analysis reveals 15 families, with the largest spanning all collection sites within the radioactive exclusion zone, reflecting migration of dogs between the power plant and Chernobyl City. This study presents the first characterization of a domestic species in Chernobyl, establishing their relevance for genetic studies into the effects of exposure to long-term, low-dose ionizing radiation.
Overall design free-breeding dogs sampled from various locations near the Chernobyl Nuclear Power Plant
Contributor(s) Spatola GJ, Buckley RM, Dillon M, Dutrow EV, Betz JA, Pilot M, Parker HG, Bogdanowicz W, Thomas R, Chyzhevskyi I, Milinevsky G, Kleiman N, Breen M, Ostrander EA, Mousseau TA
Citation(s) 36867701
Submission date Nov 30, 2022
Last update date Apr 07, 2023
Contact name Alexander Christian Harris
Phone 301-402-2016
Organization name National Institutes of Health
Department National Human Genome Research Institute
Lab Ostrander
Street address 50 South Drive
City Bethesda
State/province Maryland
ZIP/Postal code 20892
Country USA
Platforms (1)
GPL17481 Illumina CanineHD BeadChip
Samples (299)
GSM6767517 CNPP_31
GSM6767518 CNPP_32
GSM6767519 CNPP_33
BioProject PRJNA907015

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE219090_GEO_Spatola_221129_Intensities.txt.gz 460.8 Mb (ftp)(http) TXT
GSE219090_GEO_Spatola_221129_MatrixProcessed_updated.txt.gz 822.5 Mb (ftp)(http) TXT
GSE219090_RAW.tar 803.8 Mb (http)(custom) TAR (of IDAT)
GSE219090_downsampled_final.bed.gz 1.0 Mb (ftp)(http) BED
GSE219090_downsampled_final.bim.gz 810.7 Kb (ftp)(http) BIM
GSE219090_downsampled_final.fam.gz 253 b (ftp)(http) FAM
GSE219090_downsampled_read_me.txt 893 b (ftp)(http) TXT
Processed data are available on Series record

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