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| Status |
Public on Dec 14, 2022 |
| Title |
The dogs of Chernobyl: demographic insights into populations inhabiting the nuclear exclusion zone |
| Organism |
Canis lupus familiaris |
| Experiment type |
Genome variation profiling by SNP array
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| Summary |
The 1986 Chernobyl nuclear disaster initiated a series of catastrophic events resulting in long-term and widespread environmental contamination. We characterize the genetic structure of 302 dogs representing three free-roaming dog populations living within the power plant itself, or 15-45 km from the disaster site. Genome-wide profiles from Chernobyl, purebred, and free-breeding dogs world-wide reveal that the individuals from the power plant and Chernobyl City are genetically distinct, with the former displaying increased intrapopulation genetic similarity and differentiation. Analysis of shared ancestral genome segments highlights differences in the extent and timing of western breed introgression. Kinship analysis reveals 15 families, with the largest spanning all collection sites within the radioactive exclusion zone, reflecting migration of dogs between the power plant and Chernobyl City. This study presents the first characterization of a domestic species in Chernobyl, establishing their relevance for genetic studies into the effects of exposure to long-term, low-dose ionizing radiation.
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| Overall design |
free-breeding dogs sampled from various locations near the Chernobyl Nuclear Power Plant
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| Contributor(s) |
Spatola GJ, Buckley RM, Dillon M, Dutrow EV, Betz JA, Pilot M, Parker HG, Bogdanowicz W, Thomas R, Chyzhevskyi I, Milinevsky G, Kleiman N, Breen M, Ostrander EA, Mousseau TA |
| Citation(s) |
36867701 |
| Submission date |
Nov 30, 2022 |
| Last update date |
Apr 07, 2023 |
| Contact name |
Alexander Christian Harris |
| E-mail(s) |
alex.harris@nih.gov
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| Phone |
301-402-2016
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| Organization name |
National Institutes of Health
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| Department |
National Human Genome Research Institute
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| Lab |
Ostrander
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| Street address |
50 South Drive
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| City |
Bethesda |
| State/province |
Maryland |
| ZIP/Postal code |
20892 |
| Country |
USA |
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| Platforms (1) |
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| Samples (299)
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| Relations |
| BioProject |
PRJNA907015 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE219090_GEO_Spatola_221129_Intensities.txt.gz |
460.8 Mb |
(ftp)(http) |
TXT |
| GSE219090_GEO_Spatola_221129_MatrixProcessed_updated.txt.gz |
822.5 Mb |
(ftp)(http) |
TXT |
| GSE219090_RAW.tar |
803.8 Mb |
(http)(custom) |
TAR (of IDAT) |
| GSE219090_downsampled_final.bed.gz |
1.0 Mb |
(ftp)(http) |
BED |
| GSE219090_downsampled_final.bim.gz |
810.7 Kb |
(ftp)(http) |
BIM |
| GSE219090_downsampled_final.fam.gz |
253 b |
(ftp)(http) |
FAM |
| GSE219090_downsampled_read_me.txt |
893 b |
(ftp)(http) |
TXT |
| Processed data are available on Series record |
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