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| Status |
Public on May 01, 2024 |
| Title |
Regulation of c-Myc function by centromeric protein KLIP1 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
In this study, we show that the centromeric Kaposi’s sarcoma-associated herpesvirus (KSHV) latent nuclear antigen (LANA)-interacting protein 1 (KLIP1) is a novel regulator of the c-Myc pathway. A series of microarray experiments were designed to demonstrate that the expression levels of KLIP1 protein are inversely correlated with cell proliferation, and the expression of c-Myc targets.
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| Overall design |
1 MCF7 parental cell, and 3 MCF7 cell clones with stable transfection of vector, and 4 MCF7 cell clones with stable transfection of KLIP1, all with 3 technical replicates were profiled with Phalanx microarrays to examine the differenetial expression due to the over-expression of KLIP1.
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| Contributor(s) |
Gao S, Kuhne K, Chen Y |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
May 21, 2010 |
| Last update date |
May 01, 2024 |
| Contact name |
Yidong Chen |
| E-mail(s) |
cheny8@uthscsa.edu
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| Phone |
2105629163
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| Organization name |
UT Health Science Center at San Antonio
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| Department |
Population Health Sciences
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| Street address |
8403 Floyd Curl Drive, MSC 7784
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| City |
San Antonio |
| State/province |
Texas |
| ZIP/Postal code |
78229 |
| Country |
USA |
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| Platforms (1) |
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| Samples (24)
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| GSM545895 |
Vector Clone A, rep1 |
| GSM545896 |
Vector Clone A, rep2 |
| GSM545897 |
Vector Clone A, rep3 |
| GSM545898 |
Vector Clone H, rep1 |
| GSM545899 |
Vector Clone H, rep2 |
| GSM545900 |
Vector Clone H, rep3 |
| GSM545901 |
Vector Clone I, rep1 |
| GSM545902 |
Vector Clone I, rep2 |
| GSM545903 |
Vector Clone I, rep3 |
| GSM545904 |
KLIP1 Clone F, rep1 |
| GSM545905 |
KLIP1 Clone F, rep2 |
| GSM545906 |
KLIP1 Clone F, rep3 |
| GSM545907 |
KLIP1 Clone H, rep1 |
| GSM545908 |
KLIP1 Clone H, rep2 |
| GSM545909 |
KLIP1 Clone H, rep3 |
| GSM545910 |
KLIP1 Clone J, rep1 |
| GSM545911 |
KLIP1 Clone J, rep2 |
| GSM545912 |
KLIP1 Clone J, rep3 |
| GSM545913 |
KLIP1 Clone K, rep1 |
| GSM545914 |
KLIP1 Clone K, rep2 |
| GSM545915 |
KLIP1 Clone K, rep3 |
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| Relations |
| BioProject |
PRJNA127239 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE21951_RAW.tar |
63.8 Mb |
(http)(custom) |
TAR (of GPR) |
| Processed data included within Sample table |
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