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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Oct 13, 2010 |
| Title |
Expression data from mouse colon tissue response to DSS induction at day 0, 2, 4 and 6 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Temporal genome profiling of DSS colitis
The DSS induced mouse colitis model is often used to emulate Ulcerative Colitis (UC) in order understand pathophysiological mechanism of inflammatory bowel disease (IBD). Given the progressive nature of IBD, colon tissue gene expression changes during the evolution of disease, and knowing the changes in gene expression profiles could indentify potential diagnostic markers or additional therapeutic targets for colitis. Therefore, we performed temporal genome expression profiling analysis using the Affymetrix genome wide microarray system to identify broad scale changes in gene expression associated with the development of colitis.
Keywords: Expression time course of mouse colon tissue induced by 3% DSS.
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| Overall design |
C57BL/6J mice were given 3% DSS in the drinking water and tissues from individual cohorts were collected at days 0, 2, 4 and 6. Total RNA were extracted from the colon tissue and detected by Affymerix GeneChip Mouse Genome 430 2.0 Array.
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| Contributor(s) |
Kevil CG, Fang K |
| Citation(s) |
20923862 |
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| Submission date |
Jun 11, 2010 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Kevil G Christopher |
| E-mail(s) |
ckevil@lsuhsc.edu
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| Phone |
3186754694
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| Organization name |
Louisiana State University Health Science Center, Shreveport
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| Department |
Pathology
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| Street address |
1501 Kings Highway
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| City |
Shreveport |
| State/province |
LA |
| ZIP/Postal code |
71105 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (23)
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| GSM555192 |
normal mouse colon, D0M4 |
| GSM555193 |
normal mouse colon, D0M5 |
| GSM555194 |
colon of mouse treated with DSS for 2 day, D2M1 |
| GSM555195 |
colon of mouse treated with DSS for 2 day, D2M6 |
| GSM555196 |
colon of mouse treated with DSS for 2 day, D2M7 |
| GSM555197 |
colon of mouse treated with DSS for 2 day, D2M8 |
| GSM555198 |
colon of mouse treated with DSS for 2 day, D2M17 |
| GSM555199 |
colon of mouse treated with DSS for 2 day, D2M52 |
| GSM555200 |
colon of mouse treated with DSS for 4 day, D4M1 |
| GSM555201 |
colon of mouse treated with DSS for 4 day, D4M3 |
| GSM555202 |
colon of mouse treated with DSS for 4 day, D4M4 |
| GSM555203 |
colon of mouse treated with DSS for 4 day, D4M6 |
| GSM555204 |
colon of mouse treated with DSS for 4 day, D4M7 |
| GSM555205 |
colon of mouse treated with DSS for 4 day, D4M8 |
| GSM555206 |
colon of mouse treated with DSS for 6 day, D6M1 |
| GSM555207 |
colon of mouse treated with DSS for 6 day, D6M3 |
| GSM555208 |
colon of mouse treated with DSS for 6 day, D6M4 |
| GSM555209 |
colon of mouse treated with DSS for 6 day, D6M7 |
| GSM555210 |
colon of mouse treated with DSS for 6 day, D6M21 |
| GSM555211 |
colon of mouse treated with DSS for 6 day, D6M29 |
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| Relations |
| BioProject |
PRJNA127385 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE22307_RAW.tar |
78.1 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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