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| Status |
Public on Aug 24, 2023 |
| Title |
Effect of FGF singaling inhibition on gene expression on limb bud mesenchyme explants. |
| Organism |
Gallus gallus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To investigate the role FGF signaling in limb bud development we inhibited FGF signaling in limb bud explants by treatment with 5µM SU5402, an FGFR inhibitor, or DMSO as control.
We then performed mRNA sequencing on RNA collected after 48h of treatment to analyse the effect on gene expression.
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for limb bud mesemchyme explants treated with an FGF signaling inhibitor (SU5402) or DMSO.
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| Contributor(s) |
Sedas Perez S, Towers M |
| Citation(s) |
37730682 |
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| Submission date |
Jan 22, 2023 |
| Last update date |
Sep 27, 2023 |
| Contact name |
Sofia Sedas Perez |
| E-mail(s) |
s.sedas-perez@sheffield.ac.uk
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| Organization name |
The University of Sheffield
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| Street address |
Western Bank
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| City |
Sheffield |
| ZIP/Postal code |
S10 2TN |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL26853 |
Illumina NovaSeq 6000 (Gallus gallus) |
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| Samples (6)
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| GSM6956363 |
HH20 limb bud explant, DMSO, 48h, rep 1 |
| GSM6956364 |
HH20 limb bud explant, DMSO, 48h, rep 2 |
| GSM6956365 |
HH20 limb bud explant, DMSO, 48h, rep 3 |
| GSM6956366 |
HH20 limb bud explant, SU5402, 48h, rep 1 |
| GSM6956367 |
HH20 limb bud explant, SU5402, 48h, rep 2 |
| GSM6956368 |
HH20 limb bud explant, SU5402, 48h, rep 3 |
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| Relations |
| BioProject |
PRJNA926330 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE223444_RAW.tar |
13.4 Mb |
(http)(custom) |
TAR (of TXT) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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