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| Status |
Public on Apr 09, 2023 |
| Title |
Effect of Omomyc on the in vitro growth of A375 human melanoma cell line |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Skin melanomas are highly aggressive and metastatic. Omomyc is the best MYC inhibitor currently available. We analysed the effect of Omomyc expression in a transgenic and inducible (upon Doxycycline addition) manner in melanoma cells in vitro in A375 (mutated in BRAF) melanoma cell line.
We used microarrays to detail the change in the gene expression programs induced by Omomyc on day 4.
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| |
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| Overall design |
Control or doxycycline-treated A375 cells were frozen on day 4, RNA extracted and hybridized on Affymetrix microarrays.
|
| Web link |
https://genesdev.cshlp.org/content/early/2023/04/06/gad.350078.122
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| |
|
| Contributor(s) |
Zacarias-Fluck MF, Soucek L |
| Citation(s) |
37024284 |
| Submission date |
Mar 21, 2023 |
| Last update date |
Apr 11, 2023 |
| Contact name |
Mariano F Zacarias-Fluck |
| E-mail(s) |
mzacarias@vhio.net
|
| Organization name |
Vall d'Hebron Institute of Oncology (VHIO)
|
| Department |
Preclinical and Translational Research Program
|
| Lab |
Mouse Models of Cancer Therapy
|
| Street address |
Natzaret, 115-117
|
| City |
Barcelona |
| ZIP/Postal code |
08035 |
| Country |
Spain |
| |
|
| Platforms (1) |
| GPL24324 |
[Clariom_S_Human_HT] Affymetrix Clariom S Assay HT, Human (Includes Pico Assay) |
|
| Samples (10)
|
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| Relations |
| BioProject |
PRJNA947166 |
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