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| Status |
Public on Oct 19, 2023 |
| Title |
SRCAP Mutations Drive Clonal Hematopoiesis Through Epigenetic and DNA Repair Dysregulation [Cut & Run] |
| Organism |
Mus musculus |
| Experiment type |
Other
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| Summary |
To investigate how Srcap mutations confer mutant hematopoietic stem and progenitor cells (HSPCs) with selective advantage after transplantation
We assessed SRCAP chromatin remodeling and corresponding H2A.Z incorporation using Cut-and-run sequencing
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| Overall design |
We established Srcap heterozygous mutant murine competitive transplantation model. Donor test (CD45.2+) HSPCs in the bone marrow were sored and isolated at 12 weeks post-transplantation for Cut-and-run sequencing
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| Web link |
https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(23)00358-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1934590923003582%3Fshowall%3Dtrue
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| Contributor(s) |
Chen C, Goodell MA |
| Citation(s) |
37863054 |
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| Submission date |
Apr 17, 2023 |
| Last update date |
Jan 18, 2024 |
| Contact name |
Margaret Goodell |
| E-mail(s) |
goodell@bcm.edu
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| Phone |
7137921265
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| Organization name |
Baylor College of Medicine
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| Street address |
1 Baylor Plz, Rm N1030
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| City |
HOUSTON |
| State/province |
TX |
| ZIP/Postal code |
77030 |
| Country |
USA |
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| Platforms (1) |
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| Samples (24)
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| GSM7179208 |
CaR, HSPC, WT, NT, H3K27me3 |
| GSM7179209 |
CaR, HSPC, Mut, NT, H3K27me3 |
| GSM7179210 |
CaR, HSPC, WT, NT, mIgG |
| GSM7179211 |
CaR, HSPC, Mut, NT, mIgG |
| GSM7179212 |
CaR, HSPC, WT, NT, H2AZ, rep1 |
| GSM7179213 |
CaR, HSPC, WT, NT, H2AZ, rep2 |
| GSM7179214 |
CaR, HSPC, Mut, NT, H2AZ, rep1 |
| GSM7179215 |
CaR, HSPC, Mut, NT, H2AZ, rep2 |
| GSM7179216 |
CaR, HSPC, WT, NT, SRCAP, rep1 |
| GSM7179217 |
CaR, HSPC, WT, NT, SRCAP, rep2 |
| GSM7179218 |
CaR, HSPC, Mut, NT, SRCAP, rep1 |
| GSM7179219 |
CaR, HSPC, Mut, NT, SRCAP, rep2 |
| GSM7179220 |
CaR, HSPC, WT, Trx, H3K27me3 |
| GSM7179221 |
CaR, HSPC, Mut, Trx, H3K27me3 |
| GSM7179222 |
CaR, HSPC, WT, Trx, mIgG |
| GSM7179223 |
CaR, HSPC, Mut, Trx, mIgG |
| GSM7179224 |
CaR, HSPC, WT, Trx, H2AZ, rep1 |
| GSM7179225 |
CaR, HSPC, WT, Trx, H2AZ, rep2 |
| GSM7179226 |
CaR, HSPC, Mut, Trx, H2AZ, rep1 |
| GSM7179227 |
CaR, HSPC, Mut, Trx, H2AZ, rep2 |
| GSM7179228 |
CaR, HSPC, WT, Trx, SRCAP, rep1 |
| GSM7179229 |
CaR, HSPC, WT, Trx, SRCAP, rep2 |
| GSM7179230 |
CaR, HSPC, Mut, Trx, SRCAP, rep1 |
| GSM7179231 |
CaR, HSPC, Mut, Trx, SRCAP, rep2 |
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| This SubSeries is part of SuperSeries: |
| GSE230155 |
SRCAP Mutations Drive Clonal Hematopoiesis Through Epigenetic and DNA Repair Dysregulation |
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| Relations |
| BioProject |
PRJNA956487 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE229864_RAW.tar |
2.4 Gb |
(http)(custom) |
TAR (of BW) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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