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| Status |
Public on Jan 17, 2024 |
| Title |
Gene expression data of APC-mutated colorectal cancer patient-derived cells treated with tankyrase inhibitors |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Tankyrase, a poly(ADP-ribose) polymerase family member, regulates multiple cellular processes. Tankyrase inhibitors efficiently suppress APC-mutated colorectal cancer (CRC) cell proliferation. To examine the mechanism of anti-proliferative effect of tankyrase inhibitors (G007LK and RK582), we analyzed gene expression profiles of patient-derived APC-mutated CRC cells (JC21 and JC475) left untreated or treated with 0.3 µM G007LK or RK582 for 24 h by cDNA microarray analysis.
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| Overall design |
The patient-derived CRC cells, JC21 and JC475, were left untreated (DMSO) or treated with 0.3 µM G007LK or RK582 for 24 h. After the treatment, cells were collected and then gene expression data were obtained.
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| Contributor(s) |
Chen M, Mashima T, Muramatsu Y, Shirai F, Nagayama S, Katayama R, Seimiya H |
| Citation(s) |
37968472 |
| |
| Submission date |
May 10, 2023 |
| Last update date |
Jan 18, 2024 |
| Contact name |
Tetsuo Mashima |
| E-mail(s) |
ttmjmj@gmail.com
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| Phone |
81-3-3520-0111
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| Organization name |
Japanese Foundation for Cancer Research
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| Department |
Cancer Chemotherapy Center
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| Lab |
Division of Molecular Biotherapy
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| Street address |
Koto-ku, Ariake 3-8-31
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| City |
Tokyo |
| ZIP/Postal code |
135-8550 |
| Country |
Japan |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA971219 |
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