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Series GSE233735 Query DataSets for GSE233735
Status Public on Nov 20, 2023
Title HSP27 (Heat Shock Protein 27, HSPB1) overexpression effect on bleomycin-induced PF (Pulmonary fibrosis) mice model
Organism Mus musculus
Experiment type Expression profiling by array
Summary To analyze the role of HSP27 in bleomycin (BLM)-induced pulmonary fibrosis in vivo, we used TG mice that conventionally overexpressed HSP27. Our previously reported that HSP27 plays an important role in pulmonary fibrosis. In mice overexpressing HSPB1, BLM-induced fibrotic regions and collagen deposits were increased compared with those in control BL6 mice. Following intratracheal treatment of BLM, the HSP25 TG mice showed an abundance of mononuclear and neutrophils cells in the alveoli, greater destruction of alveolar septa, intra-alveolar hyaline membrane formation, and a marked increase in collagen deposition compared with control BL6 mice.
Overall design In the analysis of the study, the mice were intratracheally injected with BLM (1.25mg/kg). Mice were sacrificed at 2 weeks after BLM treatment.
Contributor(s) Lee Y, Yoo Y, Jeon S, Jin H
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Submission date May 30, 2023
Last update date Nov 20, 2023
Contact name Yun-Sil Lee
Organization name Ewha Womans University
Department College of Pharmacy
Street address 52, Ewhayeodae-gil, Seodaemun-gu
City Seoul
ZIP/Postal code 03760
Country South Korea
Platforms (1)
GPL11202 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)
Samples (2)
GSM7433471 C57BL6/N_Bleomcyin (1.25mg/kg)
GSM7433472 C57BL6/N_HSP27Overexpression Transgenic(TG)_Bleomcyin (1.25mg/kg)
BioProject PRJNA977674

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE233735_RAW.tar 4.3 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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