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Status |
Public on Jul 06, 2023 |
Title |
DNA methylation changes in mice induced by mock parabiosis |
Platform organisms |
Macaca mulatta; Homo sapiens; Mus musculus; Rattus |
Sample organism |
Mus musculus |
Experiment type |
Methylation profiling by array
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Summary |
Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation and loss of function, leading to increases in morbidity and mortality. However, recent in vitro studies have raised the possibility of age reversal. We characterized several models in which biological age, assessed primarily through analysis of DNA methylation, undergoes reversible changes. Heterochronic parabiosis is one such example.
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Overall design |
We studied a mouse model of mock parabiosis. Mouse pairs (either age-mismatched, heterochronic; or age-matched, isochronic) were subjected to sham parabiosis and maintained for 5 weeks. After this period, mice were euthanized and tissues were collected for analysis. We subjected DNA isolated from these samples to the HorvathMammalMethylChip320 for methylation profiling.
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Contributor(s) |
Poganik JR, Zhang B, Baht GS, Tyshkovskiy A, Deik A, Kerepesi C, Yim SH, Lu AT, Haghani A, Gong T, Hedman AM, Andolf E, Lee DE, Trapp A, Bareja A, McKay LK, Shindyapina AV, Dmitriev SE, Pershagen G, Almqvist C, Clish CB, Horvath S, White JP, Gladyshev VN |
Citation(s) |
37086720, 37500973 |
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Submission date |
Jul 05, 2023 |
Last update date |
Mar 01, 2024 |
Contact name |
Jesse Poganik |
Organization name |
Brigham and Women's Hospital, Harvard Medical School
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Department |
Medicine/Genetics
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Street address |
77 Avenue Louis Pasteur
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City |
Boston |
State/province |
MA |
ZIP/Postal code |
02115 |
Country |
USA |
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Platforms (1) |
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Samples (36)
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GSM7566429 |
genomic DNA from Blood from ShamOldHet5 |
GSM7566430 |
genomic DNA from Liver from ShamOldHet3 |
GSM7566431 |
genomic DNA from Liver from ShamOldHet5 |
GSM7566432 |
genomic DNA from Liver from ShamOldHet1 |
GSM7566433 |
genomic DNA from Blood from ShamOldHet1 |
GSM7566434 |
genomic DNA from Blood from ShamOldHet4 |
GSM7566435 |
genomic DNA from Blood from ShamOldHet3 |
GSM7566436 |
genomic DNA from Liver from ShamOldHet2 |
GSM7566437 |
genomic DNA from Blood from ShamOldHet2 |
GSM7566438 |
genomic DNA from Liver from ShamOldHet4 |
GSM7566439 |
genomic DNA from Liver from ShamOldIso6 |
GSM7566440 |
genomic DNA from Blood from ShamOldIso5 |
GSM7566441 |
genomic DNA from Liver from ShamOldIso1 |
GSM7566442 |
genomic DNA from Blood from ShamOldIso2 |
GSM7566443 |
genomic DNA from Liver from ShamOldIso5 |
GSM7566444 |
genomic DNA from Liver from ShamOldIso2 |
GSM7566445 |
genomic DNA from Blood from ShamOldIso3 |
GSM7566446 |
genomic DNA from Liver from ShamOldIso3 |
GSM7566447 |
genomic DNA from Blood from ShamOldIso1 |
GSM7566448 |
genomic DNA from Liver from ShamOldIso4 |
GSM7566449 |
genomic DNA from Blood from ShamOldIso4 |
GSM7566450 |
genomic DNA from Liver from ShamYoungHet4 |
GSM7566451 |
genomic DNA from Liver from ShamYoungHet3 |
GSM7566452 |
genomic DNA from Liver from ShamYoungHet1 |
GSM7566453 |
genomic DNA from Liver from ShamYoungHet2 |
GSM7566454 |
genomic DNA from Liver from ShamYoungHet5 |
GSM7566455 |
genomic DNA from Blood from ShamYoungIso1 |
GSM7566456 |
genomic DNA from Blood from ShamYoungIso4 |
GSM7566457 |
genomic DNA from Blood from ShamYoungIso2 |
GSM7566458 |
genomic DNA from Blood from ShamYoungIso5 |
GSM7566459 |
genomic DNA from Blood from ShamYoungIso3 |
GSM7566460 |
genomic DNA from Liver from ShamYoungIso2 |
GSM7566461 |
genomic DNA from Liver from ShamYoungIso4 |
GSM7566462 |
genomic DNA from Liver from ShamYoungIso3 |
GSM7566463 |
genomic DNA from Liver from ShamYoungIso1 |
GSM7566464 |
genomic DNA from Liver from ShamYoungIso5 |
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This SubSeries is part of SuperSeries: |
GSE224447 |
DNA methylation and gene expression changes in mice induced by parabiosis and recovery |
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Relations |
BioProject |
PRJNA991712 |
Supplementary file |
Size |
Download |
File type/resource |
GSE236617_ParabiosisGEOpval_P27.csv.gz |
39.1 Mb |
(ftp)(http) |
CSV |
GSE236617_RAW.tar |
207.9 Mb |
(http)(custom) |
TAR (of IDAT) |
Processed data included within Sample table |
Processed data are available on Series record |
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