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Series GSE236617 Query DataSets for GSE236617
Status Public on Jul 06, 2023
Title DNA methylation changes in mice induced by mock parabiosis
Platform organisms Macaca mulatta; Homo sapiens; Mus musculus; Rattus
Sample organism Mus musculus
Experiment type Methylation profiling by array
Summary Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation and loss of function, leading to increases in morbidity and mortality. However, recent in vitro studies have raised the possibility of age reversal. We characterized several models in which biological age, assessed primarily through analysis of DNA methylation, undergoes reversible changes. Heterochronic parabiosis is one such example.
 
Overall design We studied a mouse model of mock parabiosis. Mouse pairs (either age-mismatched, heterochronic; or age-matched, isochronic) were subjected to sham parabiosis and maintained for 5 weeks. After this period, mice were euthanized and tissues were collected for analysis. We subjected DNA isolated from these samples to the HorvathMammalMethylChip320 for methylation profiling.
 
Contributor(s) Poganik JR, Zhang B, Baht GS, Tyshkovskiy A, Deik A, Kerepesi C, Yim SH, Lu AT, Haghani A, Gong T, Hedman AM, Andolf E, Lee DE, Trapp A, Bareja A, McKay LK, Shindyapina AV, Dmitriev SE, Pershagen G, Almqvist C, Clish CB, Horvath S, White JP, Gladyshev VN
Citation(s) 37086720, 37500973
Submission date Jul 05, 2023
Last update date Mar 01, 2024
Contact name Jesse Poganik
Organization name Brigham and Women's Hospital, Harvard Medical School
Department Medicine/Genetics
Street address 77 Avenue Louis Pasteur
City Boston
State/province MA
ZIP/Postal code 02115
Country USA
 
Platforms (1)
GPL32543 HorvathMammalMethylChip320
Samples (36)
GSM7566429 genomic DNA from Blood from ShamOldHet5
GSM7566430 genomic DNA from Liver from ShamOldHet3
GSM7566431 genomic DNA from Liver from ShamOldHet5
This SubSeries is part of SuperSeries:
GSE224447 DNA methylation and gene expression changes in mice induced by parabiosis and recovery
Relations
BioProject PRJNA991712

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE236617_ParabiosisGEOpval_P27.csv.gz 39.1 Mb (ftp)(http) CSV
GSE236617_RAW.tar 207.9 Mb (http)(custom) TAR (of IDAT)
Processed data included within Sample table
Processed data are available on Series record
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