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| Status |
Public on Aug 06, 2023 |
| Title |
The mRNA-lncRNA-circRNA network profiling of Turner syndrome patient-derived induced pluripotent stem cells and their derived cardiomyocytes |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
Non-coding RNA profiling by array
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| Summary |
Heart deformity is the leading cause of mortality in Turner syndrome (TS) patients. To investigate the dysregulated ceRNA network in cardiomyocytes (CMs) of TS patients, we employed a ceRNA microarray to profile the mRNA-lncRNA-circRNA network in induced pluripotent stem cells (iPSCs) and their derived CMs from healthy donors (WT) and TS patients.
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| Overall design |
3 WT and 3 TS patient-derived iPSC lines were generated from PBMCs. CMs were derived from these iPSC lines, respectively. The mRNA-lncRNA-circRNA networks in the WT and TS-derived iPSC and CM lines were examined with ceRNA microarrays that were capable of profiling 18k mRNAs, 68k lncRNAs and 88k circRNAs.
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| Contributor(s) |
Luo Y, Zhu D |
| Citation(s) |
38124119 |
| Submission date |
Aug 01, 2023 |
| Last update date |
Jan 02, 2024 |
| Contact name |
Detu Zhu |
| E-mail(s) |
zdt@gen-turn.com
|
| Phone |
+8616624686232
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| Organization name |
The Third Affiliated Hospital of Guangzhou Medical University
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| Street address |
63
|
| City |
Guangzhou |
| State/province |
Guangdong |
| ZIP/Postal code |
510150 |
| Country |
China |
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| Platforms (1) |
| GPL22120 |
Agilent-078298 human ceRNA array V1.0 4X180K [Probe Name Version] |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA1000924 |
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