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| Status |
Public on May 01, 2011 |
| Title |
Gene and exon expression change in cardiac hypertrophy with pressure overload |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Pathological cardiac hypertrophy was induced by pressure overload on the heart. We performed genome-wide exon array experiments with left ventricles of mice with 1 week and 4 week of transverse aortic constriction (TAC). The exon level analysis revealed widespread regulation of alternative splicing and alternative polyadenylation during hypertrophy.
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| Overall design |
Exon and gene expression changes were examined in 1 week and 4 week TAC-operated hearts compared to sham-operated hearts. We used C57/BL6 wildtype mice, and their left ventricles were subject to surgery (each n=2).
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| Contributor(s) |
Park J, Li W, Zheng D, Zhao Y, Matsuda T, Vatner SF, Sadoshima J, Tian B |
| Citation(s) |
21799842 |
| |
| Submission date |
Sep 21, 2010 |
| Last update date |
Mar 06, 2018 |
| Contact name |
Jiyeon Park |
| E-mail(s) |
parkji7@snu.ac.kr
|
| Organization name |
Seoul National Univerisy
|
| Department |
Biomedical Informatics
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| Lab |
Bioinformatics
|
| Street address |
103 Daehak-ro, Jongno-gu
|
| City |
Seoul |
| ZIP/Postal code |
110-799 |
| Country |
South Korea |
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| Platforms (1) |
| GPL6096 |
[MoEx-1_0-st] Affymetrix Mouse Exon 1.0 ST Array [transcript (gene) version] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA133015 |
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