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| Status |
Public on Sep 23, 2023 |
| Title |
Response of the amnion to intrauterine inflammation and effects of inhibition of TNF signaling in preterm Rhesus macaque |
| Organisms |
Macaca mulatta; Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We demonstrate that during chorioamnionitis the amnion transcriptome is dominated by immune and inflammation related genes, largely driven by the NF-kB pathway. The amnion mesenchymal cells expressing We demonstrated that during chorioamnionitis the amnion transcriptome is dominated by immune and inflammation related genes, largely driven by the NF-kB pathway. CD14 and other myeloid cell markers increase in number with increased expression of innate immune activation markers during intrauterine infections.
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| Overall design |
We compared transcriptomics of the amnion in a preterm rhesus macaque model of IUI-induced by lypopolysaccharide with human cohorts of chorioamnionitis.
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| Web link |
https://www.cell.com/iscience/fulltext/S2589-0042(23)02195-8
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| Contributor(s) |
Presicce P, Cappelletti M, Morselli M, Ma F, Senthamaraikannan P, Protti G, Nadel BB, Aryan L, Eghbali M, Lukasz S, Pithia N, De Franco E, Miller LA, Pellegrini M, Jobe AH, Chougnet CA, Kallapur SG |
| Citation(s) |
37953944 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| U01 ES029234 |
Prenatal inflammatory exposures and neonatal immune development |
CHILDREN'S HOSPITAL MEDICAL CENTER |
Claire A Chougnet |
| R01 HD098389 |
Anti-inflammatory drug target to reduce adverse pregnancy outcomes. |
UNIVERSITY OF CALIFORNIA LOS ANGELES |
Suhas Kallapur |
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| Submission date |
Sep 22, 2023 |
| Last update date |
Dec 27, 2023 |
| Contact name |
Suhas G Kallapur |
| Organization name |
UCLA
|
| Street address |
10833 Le Conte Avenue
|
| City |
Los Angeles |
| ZIP/Postal code |
90095 |
| Country |
USA |
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| Platforms (2) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
| GPL27943 |
Illumina NovaSeq 6000 (Macaca mulatta) |
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| Samples (38)
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| Relations |
| BioProject |
PRJNA1020127 |
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