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| Status |
Public on Feb 14, 2024 |
| Title |
Ongoing Production of Tissue-Resident Macrophages from Hematopoietic Stem Cells in Healthy Adult Macaques [RNA-seq] |
| Organism |
Macaca mulatta |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To understand the ontogeny and longevity of tissue-resident macrophages in nonhuman primates (NHPs), we employ a model of autologous hematopoietic stem progenitor cell (HSPC) transplantation with HSPCs genetically modified to be marked with clonal barcodes, allowing for subsequent analysis of clonal ontogeny.
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| Overall design |
Macrophages from animals that had been transplanted with barcode- and GFP-labeled stem cells were compared with non-GFP macrophages and macrophages from control, unmanipulated animals.
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| Contributor(s) |
Rahmberg AR, Wu C, Shin T, Hong SG, Pei L, Markowitz TE, Hickman HD, Dunbar CE, Brenchley JM |
| Citation(s) |
38048388 |
| Submission date |
Oct 26, 2023 |
| Last update date |
Feb 14, 2024 |
| Contact name |
Jason Brenchley |
| E-mail(s) |
jbrenchl@niaid.nih.gov
|
| Organization name |
NIAID
|
| Street address |
4 Center Drive
|
| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
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| Platforms (1) |
| GPL27943 |
Illumina NovaSeq 6000 (Macaca mulatta) |
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| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE246351 |
Ongoing Production of Tissue-Resident Macrophages from Hematopoietic Stem Cells in Healthy Adult Macaques |
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| Relations |
| BioProject |
PRJNA1032592 |
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