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Series GSE246644 Query DataSets for GSE246644
Status Public on Jan 29, 2024
Title Malignant peripheral nerve sheath tumor (MPNST) and MPNST-like entities defined by DNA methylation profile in pediatric and juvenile population
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary The diagnosis of Malignant peripheral nerve sheath tumors (MPNSTs) can be challenging, but is aided by their characteristic DNA methylation profile (DMP). An MPNST-like group, characterized by retained H3K27me3 expression, was recently recognized. To evaluate the diagnostic usefulness of DMP in pediatric/juvenile MPNSTs, we selected pediatric/juvenile malignancies from the Bambino Gesù Children's Hospital DMP database. DMP revealed unexpected molecular heterogeneity in histologically homogenous MPNSTs/Atypical neurofibromas, while samples with MPNST-like DMP manifested histological diversity. In conclusion, DMP is useful in diagnosing MPNST, discriminating morphologic mimics classified as MPNST in premolecular era, and investigating the MPNST-like ‘hybrid’ group in pediatrics.
 
Overall design Bisulphite converted DNA from the 42 samples were hybridised to the Illumina Infinium MethylationEPIC Beadchip v1
 
Contributor(s) Miele E
Citation(s) 38178234
Submission date Oct 31, 2023
Last update date Jan 30, 2024
Contact name Evelina Miele
E-mail(s) evelina.miele@opbg.net
Organization name Ospedale Pediatrico Bambino Gesù
Department Oncoematologia
Street address Piazza di Sant'Onofrio 4
City Rome
ZIP/Postal code 00165
Country Italy
 
Platforms (1)
GPL21145 Infinium MethylationEPIC
Samples (42)
GSM7873935 genomic DNA from MPNST; case 1
GSM7873936 genomic DNA from Malignant Triton Tumor; case 2
GSM7873937 genomic DNA from Malignant Triton Tumor; case 3
Relations
BioProject PRJNA1034033

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE246644_RAW.tar 748.1 Mb (http)(custom) TAR (of IDAT)

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