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| Status |
Public on Nov 26, 2023 |
| Title |
A study of genetic variants associated with skin traits in the Vietnamese population |
| Organism |
Homo sapiens |
| Experiment type |
SNP genotyping by SNP array
|
| Summary |
Background: Most skin-related traits have been studied in Caucasian genetic backgrounds. A comprehensive study on skin-associated genetic effects on underrepresented populations such as Vietnam is needed to fill the gaps in the field. Objectives: We aimed to develop a computational pipeline to predict the effect of genetic factors on skin traits using public data (GWAS catalogs and whole-genome sequencing (WGS) data from the 1000 Genomes Project-1KGP) and in-house Vietnamese data (WGS and genotyping by SNP array). Also, we compared the genetic predispositions of 25 skin-related traits of Vietnamese population to others to acquire population-specific insights regarding skin health. Results: The skin-related genetic profile of Vietnamese cohorts was similar at most to East Asian cohorts (JPT: Fst=0.036, CHB: Fst=0.031, CHS: Fst=0.027, CDX: Fst=0.025) in the population study. In addition, we identified pairs of skin traits at high risk of frequent co-occurrence (such as skin aging and wrinkles (r = 0.45, p =1.50e-5) or collagen degradation and moisturizing (r = 0.35, p = 1.1e-3)).
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| Overall design |
Methods: Vietnamese cohorts of whole-genome sequencing (WGS) of 1008 healthy individuals for the reference and 96 genotyping samples (which do not have any skin cutaneous issues) by Infinium Asian Screening Array-24 v1.0 BeadChip were employed to predict skin-associated genetic variants of 25 skin-related and micronutrient requirement traits in population analysis and correlation analysis. Simultaneously, we compared the landscape of cutaneous issues of Vietnamese people with other populations by assessing their genetic profiles.
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| Web link |
https://pubmed.ncbi.nlm.nih.gov/38212682/
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| Citation(s) |
38212682 |
| |
| Submission date |
Nov 22, 2023 |
| Last update date |
Mar 07, 2024 |
| Contact name |
Tham H Hoang |
| E-mail(s) |
tham.hoang@uconn.edu
|
| Organization name |
Vingroup Big Data Institute
|
| Street address |
Floor 9th, 458 Minh Khai
|
| City |
Hanoi |
| ZIP/Postal code |
000000 |
| Country |
Viet Nam |
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| Platforms (1) |
| GPL33106 |
Infinium Asian Screening Array-24 v1.0 BeadChip |
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| Samples (96)
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| Relations |
| BioProject |
PRJNA1044109 |
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