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| Status |
Public on May 13, 2024 |
| Title |
Inhalation exposure to CMIT/MIT in Drosophila melanogaster |
| Organism |
Drosophila melanogaster |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The fly is a powerful tool for studying complex biological processes, with more than 60% of genes associated with various diseases and genetic similarities to humans. Based on the genetic advantages of this model organism, our study aims to perform a toxicogenic assessment of human health impact induced by the CMIT/MIT (chloromethyl-Methylisothiazolone).
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| Overall design |
The flies of both sexes were exposed to CMIT/MIT aerosol for 1 hour at 330 mg/m3. Previous observations indicate that the survival rate of flies exposed to CMIT/MIT at this concentration is approximately 81.5% on average for days 1,2, and 7. To study into the molecular and transcriptional alteration underlying this response, we analyzed the RNA Seq-based transcriptome profiles of CMIT-MIT exposed flies on day 1, 2, and 7 with 1.5-fold change > and p < 0.05.
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| Contributor(s) |
Cho Y, Kim M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Apr 09, 2024 |
| Last update date |
May 13, 2024 |
| Contact name |
Yoon Cho |
| E-mail(s) |
yoon.cho@kitox.re.kr
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| Organization name |
Korea Institute of Toxiology
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| Street address |
30, Baekhak 1-gil
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| City |
Jeongeup |
| State/province |
Jeollabuk-do |
| ZIP/Postal code |
56212 |
| Country |
South Korea |
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| Platforms (1) |
| GPL22106 |
NextSeq 550 (Drosophila melanogaster) |
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| Samples (36)
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| Relations |
| BioProject |
PRJNA1098082 |
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