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GEO help: Mouse over screen elements for information. |
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| Status |
Public on May 20, 2024 |
| Title |
Analysis of Gene Expression in the Recovered Mouse Brain following Zika Virus Infection |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Zika virus (ZIKV) is a member of the Flaviviridae family, transmitted by Aedes mosquitoes. ZIKV can be transmitted from pregnant woman to fetus and causes microcephaly and neuronal defects. Patients infected with ZIKV showed increased levels of proinflammatory cytokines compared to healthy individuals and neurological changes even after recovery. However, the detailed mechanism of how neuronal defects occurs after recovery from ZIKV infection has never been investigated in vivo. Here, we found that viral RNA loads were highest in mouse brain tissue 7 days after ZIKV infection and were equivalent to uninfected controls after 21 days, suggesting that mice recovered after 21 days of ZIKV infection. To explore the pathological mechanisms of neuronal defects after recovery from ZIKV infection, we performed RNA-sequencing in mouse cerebral cortex obtained 7 days and 21 days after ZIKV infection.
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| Overall design |
Gene expression profiling analysis of RNA-seq data from ZIKV-infected mouse brains at 7 and 21 days post-infection
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| Contributor(s) |
Kim N |
| Citation(s) |
39273400 |
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| Submission date |
Apr 25, 2024 |
| Last update date |
Oct 08, 2024 |
| Contact name |
Nahyun Kim |
| E-mail(s) |
knh64@naver.com
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| Organization name |
Konkuk university
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| Street address |
120 Neungdong-ro, Gwangjin-gu, Seoul
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| City |
Seoul |
| ZIP/Postal code |
05025 |
| Country |
South Korea |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (9)
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| GSM8230141 |
Cerebral cortex, Uninfected control, Bio rep1 |
| GSM8230142 |
Cerebral cortex, Uninfected control, Bio rep2 |
| GSM8230143 |
Cerebral cortex, Uninfected control, Bio rep3 |
| GSM8230144 |
Cerebral cortex, 7days after ZIKV infection, Bio rep1 |
| GSM8230145 |
Cerebral cortex, 7days after ZIKV infection, Bio rep2 |
| GSM8230146 |
Cerebral cortex, 7days after ZIKV infection, Bio rep3 |
| GSM8230147 |
Cerebral cortex, 21days after ZIKV infection, Bio rep1 |
| GSM8230148 |
Cerebral cortex, 21days after ZIKV infection, Bio rep2 |
| GSM8230149 |
Cerebral cortex, 21days after ZIKV infection, Bio rep3 |
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| Relations |
| BioProject |
PRJNA1104568 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE265861_RAW.tar |
162.6 Mb |
(http)(custom) |
TAR (of GTF) |
SRA Run Selector |
| Raw data are available in SRA |
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