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| Status |
Public on Jan 01, 2013 |
| Title |
Differential gene expression from microarray analysis distinguishes woven and lamellar bone formation in the rat ulna following mechanical loading |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
The objective of our study was to use a microarray to distinguish the molecular responses between woven and lamellar bone formation induced through mechanical loading. The micorarray identified numerous genes and pathways that were differentially regulated for woven, but not lamellar bone formation.
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| Overall design |
Rat forelimb loading was completed in a single bout to induce the formation of woven bone (WBF loading) or lamellar bone (LBF loading). A set of normal (non-loaded) rats were used as controls. Microarrays were performed at three timepoints after loading: 1 hr, 1 day and 3 days.
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| Contributor(s) |
McKenzie JA, Bixby EC, Silva MJ |
| Citation(s) |
22216249 |
| |
| Submission date |
Feb 04, 2011 |
| Last update date |
Jul 29, 2014 |
| Contact name |
Jennifer McKenzie |
| E-mail(s) |
mckenziej@wudosis.wustl.edu
|
| Phone |
3144548198
|
| Fax |
3143620334
|
| Organization name |
Washington University in St. Louis
|
| Department |
Orthopedic Surgery
|
| Lab |
Silva Lab
|
| Street address |
660 S. Euclid, Box 8233
|
| City |
St. Louis |
| State/province |
MO |
| ZIP/Postal code |
63110 |
| Country |
USA |
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| Platforms (1) |
| GPL6101 |
Illumina ratRef-12 v1.0 expression beadchip |
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| Samples (48)
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| Relations |
| BioProject |
PRJNA137611 |
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