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| Status |
Public on Mar 01, 2011 |
| Title |
Preactivation of the interferon signaling in liver is correlated with non-response to interferon alpha therapy in patients chronically infected with hepatitis B virus |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
To screen the differentially expressed genes between responders(Rs) and nonresponders(NRs) in CHB patients treated with IFN-α, and to explore the molecular basis for treatment failure.Expression profiling was performed on percutaneous needle liver biopsy specimens taken before therapy.Gene expression levels were compared between 7 NRs and 6 Rs,Gene Ontology category and KEGG pathway were analyzed for differentially expressed genes, and the selected differentially expressed genes were confirmed using real-time polymerase chain reaction.NRs and Rs have different liver gene expression profiles before IFN-α treatment. Preactivation of the IFN signaling pathway leading to the increased expression of inhibitory ISGs and inhibition of immune response in the pretreatment livers were associated with NRs.
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| Overall design |
Expression profiling was performed on percutaneous needle liver biopsy specimens taken before therapy.Gene expression levels were compared between 7 NRs and 6 Rs.
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| Contributor(s) |
Xiao C, Qin B, Chen L, Gong L, Liu H, Zhu Y, Lu X |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Feb 28, 2011 |
| Last update date |
Jan 23, 2019 |
| Contact name |
chunyan Xiao |
| E-mail(s) |
chunyan_xiao123@yahoo.cn
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| Organization name |
The First Affiliated Hospital, Chongqing Medical University
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| Department |
Department of Infectious Diseases
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| Street address |
No.1 Youyi Road, Yuzhong District
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| City |
Chongqing |
| ZIP/Postal code |
400016 |
| Country |
China |
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| Platforms (1) |
| GPL6480 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version) |
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| Samples (13)
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| Relations |
| BioProject |
PRJNA138295 |
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