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| Status |
Public on Sep 12, 2024 |
| Title |
Transcriptomics-based anti-tuberculous mechanism of traditional Chinese polyherbal preparation NiuBeiXiaoHe intermediates |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
To further investigate the therapeutic potential of NBXH in treating tuberculosis, we employ whole genome microarray expression profiling as a discovery platform. The study aimed to explore the impact of NBXH treatment on the gene expression profile of tuberculosis-infected animal models. The animal models were treated with high, medium, and low doses of NBXH. Following three months of treatment, PBMCs from each treatment group were used for whole genome microarray expression profiling analysis, alongside a control group. With a screening criterion of P <0.05 and an absolute log2FC value >1, 3454 up-regulated and 3597 down-regulated DEGs were respectively identified in the gene expression profiles of the mouse TB model treated with NBXH.
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| Overall design |
Once the tuberculosis infection model had been established, the tuberculosis-infected mouse models underwent treatment with high, medium, and low doses of NBXH intermediates, JHW for 87 days. Gene expression profiles in PBMCs were then measured, and each group underwent three independent experiments.
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| Contributor(s) |
Wu X, Liang Y, Wang N |
| Citation missing |
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| Submission date |
Sep 11, 2024 |
| Last update date |
Sep 12, 2024 |
| Contact name |
Nan Wang |
| E-mail(s) |
liuk@cqu.edu.cn
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| Organization name |
People's Liberation Army General Hospital
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| Street address |
Tuberculosis Prevention and Control Key Laboratory, Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment, Senior Department of Tuberculosis, Eighth Medical Center of PLA General Hospital
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| City |
beijing |
| ZIP/Postal code |
100091 |
| Country |
China |
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| Platforms (1) |
| GPL11202 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version) |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA1159778 |
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