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| Status |
Public on Sep 12, 2024 |
| Title |
TCA metabolism regulates DNA hypermethylation in LPS and Mycobacterium tuberculosis–induced immune tolerance |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
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| Summary |
Severe and chronic infections, including pneumonia, sepsis, and tuberculosis (TB), induce long-lasting epigenetic changes that are associated with an increase in all cause post-infectious morbidity and mortality. We show that TCA cycle also regulates epigenetics, specifically DNA methylation, after infection induced immune tolerance. This data from TB patients who received everolimus with standard of care antibiotics, and have less DNA hypermethylation demonstrating proof of concept that metabolic manipulation can mitigate epigenetic scars.
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| Overall design |
Bisulphite converted DNA was evaluated from a TB cohort from South Africa. TB patients were treated with standard of care (SOC) anti-TB Therapy with or without Everolimus . DNA methylation was evaluated from cryopreserved PBMCs at the end of TB treatment (day 180).
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| Contributor(s) |
Abhimanyu -, Longlax SC, Nishiguchi T, Ladki M, Sheikh D, Martinez AL, Mace EM, Grimm SL, Caldwell T, Portillo Varela A, Sekhar RV, Mandalakas AM, Mlotshwa M, Ginidza S, Cirillo JD, Wallis RS, Netea MG, van Crevel R, Coarfa C, DiNardo AR |
| Citation(s) |
39348545 |
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| Submission date |
Sep 12, 2024 |
| Last update date |
Oct 02, 2024 |
| Contact name |
Abhimanyu - |
| E-mail(s) |
Abhimanyua@uchicago.edu
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| Organization name |
Baylor College of Medicine
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| Lab |
DiNardo Lab
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| Street address |
one Baylor Plaza
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| City |
Houston |
| State/province |
Texas |
| ZIP/Postal code |
77054 |
| Country |
USA |
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| Platforms (1) |
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| Samples (68)
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| Relations |
| BioProject |
PRJNA1160204 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE277003_Matrix_processed.xls.gz |
311.9 Mb |
(ftp)(http) |
XLS |
| GSE277003_Matrix_signal_Intensities.xls.gz |
296.2 Mb |
(ftp)(http) |
XLS |
| GSE277003_RAW.tar |
1.1 Gb |
(http)(custom) |
TAR (of IDAT) |
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