|
| Status |
Public on Dec 06, 2005 |
| Title |
Identification of tumor immune evasion mechanism using P0 and P3 cell lines |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The emergence of immune resistance variants during immunotherapy is poorly understood. We generated a highly immune resistant cell line (P3) from a susceptible cell line (P0) by subjecting it to 3 rounds of in vivo immune selection. Subsequently, microarray analysis of P0 and P3 was performed to identify genes that may contribute to the increase in immune resistance.
Keywords: cell type comparison
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| |
|
| Overall design |
Four experimental replicates were prepared for each cell line. P0 is the control cell line, and P3 is the experimental/resistant cell line.
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| |
|
| Contributor(s) |
Lin K, Hung C, Peng S, Jie C, Pardoll DM, Wu T |
| Citation(s) |
17308126 |
| |
| Submission date |
Jun 06, 2005 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Ken-Yu Lin |
| E-mail(s) |
kenyulin@jhmi.edu
|
| Phone |
410-614-4906
|
| Organization name |
Johns Hopkins University School of Medicine
|
| Department |
Pathology
|
| Lab |
T.-C. Wu
|
| Street address |
720 Rutland Ave, Ross 512
|
| City |
Baltimore |
| State/province |
MD |
| ZIP/Postal code |
21205 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (8)
|
| GSM60397 |
tumor immune evasion - P0 cell line |
| GSM60398 |
tumor immune evasion - P0 cell line-replicate 2 |
| GSM60400 |
tumor immune evasion - P0 cell line-replicate 3 |
| GSM60401 |
tumor immune evasion - P0 cell line-replicate 4 |
| GSM60417 |
tumor immune evasion - P3 cell line |
| GSM60418 |
tumor immune evasion - P3 cell line-replicate 2 |
| GSM60420 |
tumor immune evasion - P3 cell line-replicate 3 |
| GSM60421 |
tumor immune evasion - P3 cell line-replicate 4 |
|
| Relations |
| BioProject |
PRJNA92309 |
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