|
| Status |
Public on Jul 01, 2011 |
| Title |
DMSO control and DZNep treated MOLM-14 cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We demonstrated that 3-Deazaneplanocin A (DZNep), a histone methyltransferase inhibitor, induce robust apoptosis in AML cells through increased ROS production and ER stress.
We identified a core gene signature including TXNIP, a major redox control molecule which is crucial in DZNep-induced apoptosis.
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| |
|
| Overall design |
MOLM-14 cells were treated with DMSO and DZNep 2 µM for 24 hours
|
| |
|
| Contributor(s) |
Zhou J |
| Citation(s) |
21734239 |
| |
| Submission date |
Jun 30, 2011 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Jianbiao Zhou |
| E-mail(s) |
jianbiaozhou@yahoo.com
|
| Organization name |
Cancer Science Institute Singapore
|
| Street address |
28 Medical Drive
|
| City |
Singapore |
| ZIP/Postal code |
117456 |
| Country |
Singapore |
| |
|
| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (4)
|
|
| Relations |
| BioProject |
PRJNA143569 |
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