|
| Status |
Public on Dec 02, 2005 |
| Title |
ILS/ISS Cerebellum Comparison Affy430 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Inbred Long-Sleep (ILS) and Inbred Short-Sleep (ISS) mice exhibit a large difference in a number of alcohol and drug related behaviors. This study examined the expression levels of transcripts in these strains in the cerebellum, which is a major target of ethanol’s actions in the CNS, in order to find differentially expressed candidate genes for these phenotypes. Cerebellum was specifically chosen due to the fact that Purkinje cell sensitivity to ethanol in these strains is highly correlated to "sleep time", the measure of ethanol sensitivity used with these strains. Naive mice were used because differences in sensitivity are observed upon initial exposure to ethanol.
Keywords: cerebellum, naive, untreated
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| |
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| Overall design |
Expression was assayed using the Affymetrix Expression Set 430 A and B arrays. Four mice were included in the experiment, two ILS and two ISS.
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| |
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| Contributor(s) |
MacLaren EJ, Bennett B, Johnson TE, Sikela JM |
| Citation(s) |
16465594 |
| |
| Submission date |
Aug 05, 2005 |
| Last update date |
Jan 08, 2019 |
| Contact name |
Erik James MacLaren |
| E-mail(s) |
erik.maclaren@uchsc.edu
|
| Organization name |
University of Colorado at Denver and Health Sciences Center
|
| Department |
Pharmacology
|
| Lab |
Sikela Lab
|
| Street address |
Mail Stop 8303, P.O. Box 6511
|
| City |
Aurora |
| State/province |
CO |
| ZIP/Postal code |
80045-0508 |
| Country |
USA |
| |
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| Platforms (2) |
| GPL339 |
[MOE430A] Affymetrix Mouse Expression 430A Array |
| GPL340 |
[MOE430B] Affymetrix Mouse Expression 430B Array |
|
| Samples (8)
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| Relations |
| BioProject |
PRJNA93169 |
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